Overhauser Enhanced Magnetic Resonance Imaging (OMRI)

项目2：Overhauser增强磁共振成像。（OMRI）我们已经检查了小鼠中的几种肿瘤模型以评估图像增强概况。在小鼠中生长不同类型的肿瘤，并且当肿瘤大小为1 ml时，使用Oxo 63作为造影剂进行OMRI实验。增强配置文件被发现是显着不同的肿瘤检查。黑色素瘤细胞系B16表现出最高的增强，而SCC细胞系（鳞状细胞癌）表现出最低的增强。其他细胞系如RIF-1、HT-29表现出中等程度的增强。在这些具有不同肿瘤的动物上使用Gd 3 +-DTPA的常规对比增强MRI的附加实验显示图像中的时间-强度曲线，其在每种测试的肿瘤类型中具有不同的行为。建议进行定量肿瘤中微血管密度的组织学研究，以研究图像增强与肿瘤灌注的依赖性。

Project 2: Overhauser enhanced Magnetic Resonance Imaging. (OMRI)We have examined several tumor models in mice to evaluate the image enhancement profiles. Different tumor types were grown in mice and OMRI experiments were carried out using Oxo 63 as the contrast agent when tumors were at the size of 1 ml. Enhancement profiles were found to be significantly varied in the tumors examined. The melanoma cell line B16 exhibited the highest enhancement where as the SCC cell line (squamous cell carcinoma) exhibited the least enhancement. Other cell lines such as the RIF-1, HT-29 exhibited intermediate enhancement. Additional experiments with conventional contrast enhanced MRI using Gd3+-DTPA on these animals with different tumors showed time -intensity profiles in images which had different behavior in each tumor type tested. Histologic studies quantitating the microvessel density in tumors are proposed to be carried out to study the dependence of image enhancement vs tumor perfusion.