Late Effects of Cancer Treatment

对接受放射治疗和化疗的癌症长期幸存者的研究，使我们对癌变有了重要的认识。我们与放射流行病学处合作，继续研究视网膜母细胞瘤幸存者发展为黑色素瘤。视网膜母细胞瘤的治疗信息已经可用，我们最近获得了整个队列的阳光、烟草和酒精暴露信息。死亡率分析表明，遗传性视网膜母细胞瘤后肺癌的发病率明显增加，而没有明显的吸烟过量。发病年龄比SEER报告的年龄小，基于少数数据，小细胞癌的比例不成比例。没有发现与辐射有关。我们继续在一组儿童时期接受头颈部照射的个体中进行辐射相关神经肿瘤的实地研究。我们计划再增加40名患有头颈部神经肿瘤的队列成员。

Studies of long-term survivors of cancer treated with radiation therapy and chemotherapy have led to important insights into carcinogenesis. In collaboration with the Radiation Epidemiology Branch, we have continued a study of survivors of retinoblastoma who have developed melanoma. Information on treatment for the retinoblastoma is already available, and we have recently obtained sun, tobacco, and alcohol exposure information for the entire cohort. Mortality analyses have indicated that there is a significant excess of lung cancer following heritable retinoblastoma, without any apparent excess smoking. The age of onset is younger than that reported in SEER, with a disproportionate percentage of small cell carcinoma, based on few numbers. No relationship with radiation was found. We have continued the field work for the study of radiation-related neural tumors in a cohort of individuals who received head and neck irradiation in childhood. We plan to add up to 40 additional cohort members to the study who have developed head and neck neural tumors.