The role of La and Related Protein family in ribosome biogenesis

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The La-related protein - LARP- superfamily constitute an evolutionary conserved group ofRNA Binding Proteins - RBPs. Humans contain seven LARP paralogues, a number of whichhave been shown to control ribosome biogenesis, a central process in every living cell. It ishowever unclear whether this is a conserved feature of all LARPs and the extent of theirfunctional and mechanistic overlap remains to be understood. The aim of this project is tosystematically assess the impact of each human LARP paralogue towards regulation ofribosome biogenesis, as well as revealing the molecular mechanisms of this regulation. Thisinterdisciplinary work will be conducted using integrated structural, biochemical, multi-omics,and cellular approaches,taking advantage of the complementary expertise of the twosupervisors.