Adaptive Optics for Medical Imaging

“视力障碍疾病是全球医疗保健系统的主要负担，严重损害人类的生活质量。近年来，光学相干断层扫描（OCT）、OCT血管造影（OCTA）和自适应光学（AO）等尖端技术已经改变了这些疾病的研究和治疗方式。然而，这些技术仍然面临技术障碍，阻碍了它们作为临床首选工具的广泛采用。特别是，有前途的AO-OCT和AO-OCTA组合系统设计，尽管大大加速了眼科研究，但由于人类患者运动等挑战，尚未商业化并部署在眼科护理诊所中。我在本科和研究生教育期间的简历中记录的经验为我提供了体验式学习的坚实基础。我在生物医学图像数据采集、处理、分析和可视化方面具有专业级的技能，并精通光学系统的硬件设计。具体来说，我以前的研究特别强调开发人体运动伪影的解决方案，这严重降低了生物医学图像质量。我还精通人体解剖学，特别是致盲疾病的病理影响，以及它们的生物标志物如何在生物医学图像中表现出来。在我的导师Marinko V. Sarunic教授的指导下，我准备好设计和实施研究，这些研究将部署先进的眼科工具来研究视网膜疾病的新生物标志物，包括糖尿病视网膜病变，青光眼和黄斑变性。具体而言，重点将放在设计和部署具有自适应光学相干断层扫描（AO-OCT）技术和新的图像处理软件，以补充他们的光学系统。UCL的医学物理和生物医学工程，眼科研究所和Moorfields眼科医院的部门的世界领先的组合是一个独特的交叉环境，我可以在追求预防人类失明的过程中产生新的知识。"

"Vision-robbing diseases are a major burden on the global healthcare system and a severe detriment to human quality of life. In recent years, cutting-edge technologies like optical coherence tomography (OCT), OCT angiography (OCTA), and adaptive optics (AO) have already changed how these diseases are researched and treated. However, these technologies still face technical barriers that prevent their widespread adoption as the clinical tool-of-choice. In particular, the promising AO-OCT and AO-OCTA combined system designs which, despite having greatly accelerated ophthalmology research, have yet to be commercialized and deployed in eye care clinics due to challenges like human patient motion.The experiences documented on my CV during my undergraduate and graduate education have provided me with a strong foundation in experiential learning. I have professional-grade skills in biomedical image data acquisition, processing, analysis, and visualization, and am proficient in hardware design of optical systems. Specifically, my prior research has placed special emphasis on developing solutions for human motion artifact, which severely degrades biomedical image quality. I am also well-versed in human anatomy, especially the pathological impacts of blindness-inducing diseases and how their biomarkers manifest within biomedical images. Under the guidance of my proposed supervisor, Prof. Marinko V. Sarunic, I am well-poised to design and implement research studies that will deploy advanced ophthalmic tools to investigate new biomarkers for retinal diseases including diabetic retinopathy, glaucoma, and macular degeneration. Specifically, emphasis will be placed upon the design and deployment of optical systems featuring adaptive optics optical coherence tomography (AO-OCT) technology and novel image processing software to complement them. The world-leading combination of UCL's departments of Medical Physics and Biomedical Engineering, Institute of Ophthalmology, and Moorfields Eye Hospital is a unique intersectional environment in which I may generate new knowledge in the pursuit of preventing human blindness."