BIOMEDICAL OPTICS FOR MEDICAL RESEARCH AND CLINICAL CARE

生物医学光学是一个利用光对组织进行诊断、治疗疾病和辅助手术的领域，在生物医学研究和临床护理中都有应用。俄勒冈州有专门研究生物医学光学的生物工程实验室网络和两个使用生物医学光学和医疗激光进行临床活动的医疗中心。该提案将在俄勒冈健康科学大学（OHSU）校园内建立一个生物医学光学实验室，作为核心研究设施，以支持生物工程网络中的新光学技术与OHSU医学研究和临床活动项目的接口。生物工程网络包括位于普罗维登斯圣文森特医疗中心的俄勒冈医疗激光中心（OMLC）、俄勒冈科学技术研究生院（OGI）、生物材料和生物力学系（OHSU）和俄勒冈大学光学中心（UO）。该提案将为生物工程网络提供资金，以启动新项目，并将其转化为医疗中心。生物工程网络的设计导向项目是围绕医学中心的生物医学研究人员和临床医生的假设驱动项目组织的。最初的项目分为两大主题：(1)组织工程和生物材料开发，最初重点是骨再生和生物材料植入；(2)癌症检测和治疗，最初重点是发育不良和浅表癌的光学成像，光动力化疗（光动力疗法或PDT）期间用于剂量测定和治疗评估的光纤设备，以及作为基础医学研究工具的PDT。该项目的管理和推广活动包括外部咨询委员会的年度审查，俄勒冈科学院年度会议的研讨会，以及一个包含广泛数据库和教育材料的网站。该研究项目是生物医学光学课程的补充。

Biomedical Optics is a field using light to interrogate tissues for diagnostic purposes and to treat disease and assist surgery, with applications in both biomedical research and clinical care. Oregon has a network of bioengineering laboratories specializing in biomedical optics and two medical centers with clinical activities using biomedical optics and medical lasers. This proposal would establish a Biomedical Optics Laboratory on the campus of the Oregon Health Sciences University (OHSU) as a core research facility to support the interface of new optical technologies from the bioengineering network with projects in the medical research and clinical activities at OHSU. The bioengineering network includes the Oregon Medical Laser Center at Providence St. Vincent Medical Center (OMLC), the Oregon Graduate Institute of Science and Technology (OGI), the Department of Biomaterials and Biomechanics (OHSU) and the University of Oregon Center for Optics (UO). The proposal would provide funding for the bioengineering network to initiate new projects for translation into the medical center. The design- directed projects of the bioengineering network are organized around hypothesis-driven projects of biomedical investigators and clinicians at the medical centers. The initial projects fall under two broad themes: (1) tissue engineering and biomaterials development with initial emphasis on bone regeneration and biomaterial implants, and (2) cancer detection and treatment with initial emphasis on optical imaging of dysplasia and superficial cancer, optical fiber devices for dosimetry and treatment evaluation during light-activated chemotherapy (photodynamic therapy or PDT), and PDT as a tool in basic medical research. Management and outreach activities of the program include an annual review by an external advisory board, a symposium at the annual Oregon Academy of Sciences meeting, and a website with extensive database and educational materials. The research program complements a Biomedical Optics curriculum.