Neurobiology of Insomnia as Measured with FMRI

描述（由申请人提供）：研究表明，失眠患者经常抱怨注意力不集中，记忆力受损，完成日常任务的能力下降，这些因素随着睡眠问题的严重程度增加而恶化。尽管有证据表明失眠对个人造成了重大损失，但研究对客观测量的神经心理（NP）表现缺陷一直模棱两可。在这项研究中，NP测试将与功能MRI（FMRI）相结合，以调查和评估原发性失眠症的认知表现。他的研究的具体目标是：1）比较失眠患者与匹配对照的NP测试表现，2）比较失眠患者与匹配对照的认知挑战期间脑功能的FMRI测量，以及3）检查失眠患者的FMRI BOLD信号响应与客观和主观表现测量之间的关系，以测试假设的激活增加是否代表类似于睡眠剥夺所观察到的代偿反应。未来研究的途径可能包括失眠亚型的研究（例如，主观与客观）和/或治疗失眠的新方法。

DESCRIPTION (provided by applicant): Research has shown that patients with insomnia often complain of impaired concentration, impaired memory, and decreased ability to accomplish daily tasks and that these factors worsen as their sleep problems increase in severity. Despite the evidence that insomnia exacts a significant toll on individuals, research has been equivocal as to objectively measured neuropsychological (NP) performance deficits. In this study, NP testing will be combined with functional MRI (FMRI) to investigate and assess cognitive performance in primary insomnia. The specific aims of his study are to: 1) compare patients with insomnia to matched controls on NP test performance, 2) compare patients with insomnia to matched controls on FMRI measures of brain function during cognitive challenges, and 3) examine the relationship between FMRI BOLD signal responses and objective and subjective measures of performance in patients with insomnia, to test whether hypothesized increases in activation represent compensatory responses similar to those observed with sleep deprivation. Avenues for future investigation may include studies of insomnia subtypes (e.g., subjective versus objective) and/or new approaches to treatment of insomnia.