The Role of Signal Transduction Pathways in Hypertension

描述（由申请人提供）：计划研究的目的是证实或反驳在各种高血压模型中孤立核束（NTS）中存在单独的磷脂酰肌醇3 （PI3）和丝裂原活化蛋白（MAP）激酶途径。总的目标是研究这个大脑部位的信号机制，可能有助于持续高血压的发展和维持。我们正在进行的研究旨在为各种形式高血压交感神经系统的明显增强与PI3和MAP激酶信号通路在高血压维持中的作用之间的关系提供初步信息。我们最初的目标是证明（mRen-2）27转基因大鼠NTS中的PI3和MAP激酶信号通路在Ang II与AT1受体结合时被激活。提出这项研究的基本原理是，一旦了解了导致高血压发展的机制，就可能导致可用于预防和/或治疗高血压的新策略，从而降低与高血压相关的发病率和死亡率。

DESCRIPTION (provided by applicant): The goal of the planned research is to either confirm or refute the presence of separate phosphatidylinositol 3 (PI3) and mitogen-activated protein (MAP) kinase pathways in the nucleus tract solitarius (NTS) in various models of hypertension. The overall objective is to investigate the signaling mechanisms at this brain site potentially contributing to development and maintenance of sustained hypertension. Our ongoing studies are designed to provide initial information about the relationship between the apparent enhancement of the sympathetic nervous system in various forms of hypertension and the role of PI3 and MAP kinase signaling pathways in the maintenance of hypertension. Our initial goal is to demonstrate that PI3 and MAP kinase signaling pathways in the NTS of (mRen-2)27 transgenic rats are activated in response to Ang II binding to AT1 receptors. The rationale for the proposed research is that, once knowledge of the mechanisms that are responsible for the development of hypertension has been obtained, it may lead to new strategies that can be used to prevent and/or treat hypertension, thereby reducing the morbidity and mortality associated with high blood pressure.