Contraception & Metabolic Changes in HIV-positive Women

描述（由申请人提供）：抗逆转录病毒治疗（ART）的副作用管理已成为治疗人类免疫缺陷病毒（HlV）感染者的主要焦点。这些副作用中最普遍的是代谢并发症。随着越来越多的妇女感染艾滋病毒，随着艾滋病毒/艾滋病成为一种慢性疾病而不是一种致命的诊断，越来越多的妇女将寻求建立家庭和间隔怀孕的方法，而不是终止其生育能力。然而，尽管一般文献中的研究指出，使用避孕药会导致显著的代谢失调，特别是在与艾滋病毒及其治疗的副作用重叠的领域，但尚未有研究调查避孕激素的使用是否会增加感染艾滋病毒的妇女发生代谢并发症的风险。建议对妇女机构间艾滋病毒研究（WIHS）队列进行二次数据分析，作为调查这一问题的第一步。培训计划旨在提供必要的信息背景和研究经验，使受训者能够执行研究计划。赞助商将贡献他们在艾滋病毒/艾滋病、代谢失调和研究方法方面的专业知识。

DESCRIPTION (provided by applicant): Management of the side effects of antiretroviral therapy (ART) has become a primary focus in the treatment of human immunodeficiency virus (HlV)-infected individuals. Among the most pervasive of these side effects are the metabolic complications. As more women are infected with HIV, and as HIV/AIDS becomes a chronic disease rather than a lethal diagnosis, more of these women will be looking for ways to have families and space pregnancies, rather than to terminate their ability to reproduce. However, despite research in the general literature that points to significant metabolic dysregulation with contraceptive use, especially in areas that overlap with the side effects seen in HIV and its treatment, no research has yet examined whether or not contraceptive hormone use contributes to HIV-infected women's risk for metabolic complications. A secondary data analysis of the Women's Interagency HIV Study (WIHS) cohort is proposed as an initial step towards investigating this problem. The training plan is designed to provide the informational background and research experience necessary to allow the trainee to carry out the research plan. The sponsors will contribute their expertise in HIV/AIDS, metabolic dysregulation, and research methodology.