Perfectionism in adolescents with depression

描述(申请人提供)：青少年抑郁症治疗研究(TADS)是一项由国家精神卫生研究所资助的随机对照试验，在14个地点进行。439名12至17岁被诊断患有严重抑郁障碍的青少年参加了TADS。参与者被随机分配到4种治疗方法中的一种：认知行为疗法(CBT)、氟西汀(FIX)、认知行为疗法联合氟西汀(Combo)或安慰剂(PBO)。除了主要结果衡量标准外，TADS数据集中还包括几项额外的衡量标准，将用于二次分析。我的研究将着眼于功能失调的态度在青少年抑郁症发展中的作用。具体地说，我将探索完美主义作为抑郁症状和自杀倾向方面治疗反应的可能预测因素、调节因素和/或中介。纵向数据将在大约一年内提供，并将允许测试完美主义、功能失调态度和抑郁症之间的关系模型。这些发现将有助于理解抑郁青少年的认知易感性和治疗反应机制。

DESCRIPTION (provided by applicant): The Treatment for Adolescents with Depression Study (TADS) is a randomized controlled trial funded by the National Institute of Mental Health and conducted at 14 sites. A sample of 439 adolescents between 12 and 17 years of age with a diagnosis of major depressive disorder participated in TADS. Participants were randomly assigned to 1 of 4 treatments: cognitive behavior therapy (CBT), fluoxetine (FIX), cognitive behavior therapy in combination with fluoxetine (Combo), or pill placebo (PBO). In addition to primary outcome measures, several additional measures were included in the TADS dataset and will be available for secondary analyses. My research will look at the role of dysfunctional attitudes in the development of adolescent depression. Specifically, I will explore perfectionism as a possible predictor, moderator, and/or mediator of treatment response in terms of depression symptoms and suicidality. Longitudinal data will be available in approximately 1 year and will allow for the testing of models of relations between perfectionism, dysfunctional attitudes, and depression. These findings will contribute to the understanding of cognitive vulnerability for depression and mechanisms of treatment response in depressed adolescents.