Nanoparticle Coating to Increase Biliary Stent Patency

描述（由申请人提供）： 胆道支架植入术是一种常见的做法，以减轻黄疸的症状，由于梗阻的胆管。在这个过程中，金属或塑料支架被放置在内镜下的胆管，以恢复胆汁流动，随后，缓解黄疸。虽然这些支架为90%接受支架的患者提供了症状缓解，但该技术的主要并发症是由于细菌生物膜和胆泥沉积造成的晚期支架堵塞。当细菌附着在支架表面并开始形成生物膜时，管腔不可避免地变得闭塞，并发生复发性胆道梗阻。该提案涉及开发一种用于聚乙烯胆道支架的新涂层，以提高其通畅性，减少并发症和阻塞性黄疸患者的大量住院时间。Lynntech提出了一种超光滑涂层，其最终将延迟细菌粘附和导致支架复发性阻塞的无定形材料结壳。这种新方法源于Lynntech将纳米颗粒沉积到金属或塑料表面的革命性方法，在这种情况下，将准晶体沉积到聚乙烯胆道支架上。预期经济的准晶涂层将改善聚乙烯支架的通畅性，同时保持其所需的性能，例如低成本和易于插入和移除，这些性能不是大多数金属支架所固有的。

DESCRIPTION (provided by applicant): Biliary stenting is a common practice to relieve the symptoms of jaundice due to an obstruction of the bile duct. In this procedure, a metal or plastic stent is placed endoscopically in the bile duct to restore bile flow and subsequently, relieve jaundice. Although these stents provide relief of symptoms for 90% of the patients who receive them, the major complication of the technique is late stent blockage, due to bacterial biofilm and biliary sludge deposition. As bacteria attach to the surface of the stent and begin to form a biofilm, the lumen inevitably becomes occluded and recurrent biliary obstruction occurs. This proposal concerns the development of a new coating for polyethylene biliary stents to improve their patency, reducing complications and numerous hospital stays for patients with obstructive jaundice. Lynntech proposes an ultrasmooth coating which will ultimately delay bacterial adhesion and the encrustation of amorphous material which leads to recurrent obstruction of the stent. The novel approach stems from Lynntech's revolutionary method for depositing nanoparticles onto metal or plastic surfaces, in this case quasicrystals onto polyethylene biliary stents. It is anticipated that the economic quasicrystal coating will improve polyethylene stent patency while retaining their desirable properties such as low cost and ease of insertion and removal, properties not inherent in most metal stents.