Encoded Sortable Particle Combinatorial Synthesizer

描述(由申请人提供)：对合成和筛选大型合成化合物文库的高性价比方法的巨大需求尚未得到满足。该项目将开发一种基于编码可分类粒子(ESP)技术的新型“液体阵列”定向合成平台，以生成大型、高质量的预定义内容库。ESP是一种光学编码的微细加工颗粒，可以使用磁力进行操纵。这个项目的总体目标是利用ESP技术开发一个使用定向排序策略的高效组合合成器。由于我们的组合合成器将允许直接合成任何一组化合物，它将创建定义内容的库，这些库可以比可比的随机库更快、更低的成本进行筛选，同时显示更高纯度的化合物，提供更多信息，并提供更高质量的数据。基于ESP的文库将为许多不同类型的分析提供一个广泛的平台。基于ESP的文库有潜力用于基础生物医学研究，以及高通量发现和临床诊断以及癌症和各种其他疾病的预后。

DESCRIPTION (provided by applicant): There is a tremendous unmet need for cost-effective methods of synthesizing and screening large libraries of synthetic compounds. This project will develop a novel 'liquid array' directed synthesis platform, based on Encoded Sortable Particle (ESP) technology, to generate large, high quality libraries of pre-defined content. ESPs are optically-encoded microfabricated particles that can be manipulated using magnetic force. The overall aim of this project is to use ESP technology to develop a highly efficient combinatorial synthesizer that uses a directed sort strategy. Because our combinatorial synthesizer will allow the directed synthesis of any set of compounds, it will create libraries of defined content that can be screened more rapidly and at lower cost than comparable random libraries, while displaying compounds of higher purity, providing substantially more information, and delivering data of higher quality. The ESP-based libraries will provide a broad platform for many different kinds of assays. ESP-based libraries have the potential to be used in basic biomedical research, as well as high-throughput discovery and clinical diagnosis and prognosis of cancer, and a wide variety of other diseases.