Scintillation Luminescence System for In-Vivo Dosimetry

描述（由申请人提供）： Nomadics提出开发能够产生闪烁发光（SL）的闪烁纳米复合材料，并证明其适用于体内剂量测定和辐射剂量成像。用这种材料成功生产SL表明，这种技术可用于创建一种新型的辐射检测，用于剂量测定、放射治疗剂量控制以及X射线和其他能源成像技术。基于纳米颗粒的闪烁发光系统将为体内剂量测定提供增强的灵敏度。在第一阶段，我们将专注于制造可用于体内剂量测定的闪烁纳米粒子，以支持更安全，更准确的放射癌症治疗。Nomadics将完成化学和光学开发任务，而NIH的Angelo Russo博士将进行测试以验证该方法的生物相容性。此外，俄克拉荷马州州立大学的Carey Pope博士，一位领先的毒理学家，将进行毒理学研究，以验证SL纳米颗粒用于体内剂量测定的适用性。一旦这一概念得到成功证实，它将大大改善放射治疗中的剂量控制，并通过保护邻近的健康组织而使癌症患者受益。此外，关于X射线和类似技术在医疗行业、制造业、安全领域、检查和非破坏性测试过程以及其他应用中的广泛使用，所提出的量子材料的使用具有在较低能量水平下进行更高分辨率成像的潜力，从而导致这些过程的使用的成本、复杂性、危害和其他负面方面的大幅降低。

DESCRIPTION (provided by applicant): Nomadics proposes the development of scintillation nanocomposite materials that are capable of producing scintillation luminescence (SL) and the demonstration of their applicability for in vivo dosimetry and radiation dose imaging. Successful production of SL with such materials would suggest that this technology could be used to create a new type of radiation detection for use in dosimetry, radiation therapy dose-control, and X-ray and other energy source imaging techniques. Nanoparticle-based scintillation luminescence systems would provide enhanced sensitivity for in vivo dosimetry. In Phase I, we will focus on making scintillation nanoparticles that can be used for in vivo dosimetry in support of safer, more accurate radiation cancer therapy. Nomadics will do the chemistry and optical development tasks, while Dr. Angelo Russo of NIH will conduct tests to verify the biocompatibility of the approach. Additionally, Dr. Carey Pope of Oklahoma State University, a leading toxicologist, will conduct toxicology studies to verify the suitability of SL nanoparticles for in vivo dosimetry. Once the concept is successfully demonstrated, it will be a great improvement for dose control in radiotherapy and will greatly benefit cancer patients by offering protection to adjacent healthy tissues. Additionally, with regard to the extensive use of X-ray and similar technologies in the medical industry, manufacturing, security field, inspection and non-destructive testing processes, and other applications, the proposed use of quantum materials holds the potential for higher resolution imaging at lower energy levels, resulting in substantial reductions in cost, complexity, hazards, and other negative aspects of the use of these processes.