Transfer and stability of antimicrobial resistance (AMR) genes in Methicillin-Resistant Staphylococcus aureus (MRSA)

TB抗生素耐药性(ABR)是一个日益严重的全球性问题，需要创新的、跨学科的解决方案。然而，支持耐药基因在细菌群体中转移和稳定的动力学和遗传机制尚不清楚。在这个项目中，我们将使用耐甲氧西林金黄色葡萄球菌(MRSA)的临床菌株，这是一种重要的临床病原体，来测量并表征耐药基因转移背后的遗传成分。与生物信息学分析相结合，该项目将对临床实践产生直接的翻译影响，并将告知我们对潜在的进化变化的理解，以及如何以最佳方式利用这些变化来控制ABR。

TBCAntibiotic resistance (ABR) is a growing global problem, that requires innovative, cross-disciplinary solutions. However, the dynamics and genetic mechanisms that underpin the transfer and stability of resistance genes within bacterial population is poorly understood. In this project, we will use clinical strains of methicillin resistant Staphyloccocus aureus (MRSA), an important clinical pathogen, to measure and then characterise the genetic components behind gene transfer of resistance. Paired with bioinformatic analysis, this project will have direct translational impact on clinical practice and will inform our understanding of the underlying evolutionary changes and how these can be optimally harnessed for ABR control.