Chemical biology tools to understand and modulate immune clearance of microbial infections

大多数可用的抗生素对细菌感染无效，因此迫切需要新的治疗方法。免疫系统是抵抗细菌感染的第一道防线之一，通过多种不同的机制杀死细菌。该项目旨在测试数千种分子，以找到那些只在存在免疫攻击时杀死细菌的分子。确定这些分子的靶点，并使用化学和生物学方法相结合来确定它们如何产生这些效应，将有助于其他人产生靶向治疗，以增强对细菌的免疫反应。UKRI BBSRC优先事项-对抗抗菌素耐药性-食品、营养和健康

Most available antibiotics do not work against bacterial infections, therefore new treatments are urgently needed. The immune system is one of the first lines of defence against bacterial infection that kills bacteria via a multitude of different mechanisms. This project aims to test thousands of molecules to find those that only kill bacteria when in the presence of immune attack. Determining the targets of these molecules and identifying how they produce these effects using a combination of chemistry and biology methods will help others to produce targeted treatments to boost the immune response against bacteria.UKRI BBSRC Priorities - Combatting antimicrobial resistance - Food, nutrition and health