LUPOID DERMATOSIS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。一只11个月大的完整的雄性德国短毛指示犬，全身都是片状的皮肤。主人报告说，自从这只狗在12周大时被获得以来，他的皮肤就一直保持着相同的外观。尽管使用了各种洗发水、类固醇和抗生素，情况还是一样。有时，他鼻子和脸上的病变会变得更严重，只是会再次好转，但永远不会解决。经检查，这只狗除了全身长满了皮屑外，身体健康。他的鼻子和阴囊上有一些硬壳状的损伤。分别从前额、胸部和腰部进行活检。有角化过度和局灶性角化不全。基底细胞凋亡在组织中弥漫性分布。基底细胞空泡化，真皮内有大量噬黑素细胞。有少量淋巴细胞浸润，这在狼疮犬身上很常见。然而，在咨询了宾夕法尼亚大学医院的皮肤病理学家后，确诊为皮肤红斑狼疮。这只狗被捐赠给了宾夕法尼亚大学。他将被用于繁殖以扩大种群。与此同时，我们又收到了三只德国短毛指示犬，它们患有类脂性皮肤病，两只母的，一只公的。这两只狗也将被用于繁殖，以扩大种群。所有的组织病理学评估都由伊丽莎白·莫尔丁（Elizabeth Mauldin）博士进行，她是一名委员会认证的兽医皮肤科医生和病理学家。Mauldin博士和我向诺华公司申请并获得了一笔小额赠款，用于口服环孢素（特应异）的治疗试验。这种免疫调节剂被认为可以减少或消除真皮中的细胞反应，而这种反应似乎是导致这种疾病的原因。每个月进行一次活组织检查和拍照，治疗12个月后，结果将汇总并提交给诺华公司。研究结果将在研究完成后公布。我们还收到了受感染犬及其亲属的大量皮肤活检和血液样本，分别用于组织病理学和DNA检测

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An 11 moth old intact male German Short Hair Pointer presented with extremely flaky skin all over his whole body. The owner had reported that the dog had had the same appearance to his skin ever since the dog was obtained at 12 weeks of age. Despite all types of shampoos, steroids, and antibiotics, the condition remained the same. At times, the lesions on his nose and face would get worse, only to get better again, but would never resolve. On examination, the dog appeared physically healthy except for the dander covering his whole body. There were some crusty lesions on his nose and on his scrotum. Three biopsies from the forehead, thorax and lumbar region were obtained. There was hyperkeratosis and focal parakeratosis. Basal cell apoptosis was diffusely scattered throughout the tissues. There was also basal cell vacuolation and large numbers of melanophages within the dermis. There was a minimal lymphocytic infiltrate, which should he seen with lupus in dogs. However, on consultation with the dermatopathologists at the Hospital of the University of Pennsylvania, a diagnosis of lupus of the skin was confirmed. This dog was donated to the University of Pennsylvania. He is to be used for breeding to expand the colony. In the meantime, we have received three more German shorthair pointers that are affected with lupoid dermatosis, two females and one male. Both dogs are also to be used for breeding to expand the colony, All of the histopathological evaluations are being performed by Dr. Elizabeth Mauldin, a board certified veterinary dermatologist and pathologist. Dr Mauldin and I applied for and received a small grant from Novartis for therapeutic trials of oral cyclosporine (Atopica), an immune modulator thought to reduce or eliminate cellular reactions in the dermis, which appear to cause the disease. Biopsies and photographs are being taken at monthly intervals and the results will be summarized and presented to Novartis after 12 months of treatment. The results will be published after completion of the study. We have also received numerous skin biopsies and blood samples from affected dogs and their relatives for histopathology and DNA, respectively