Center for Reducing Risks in Vulnerable Populations

描述（由申请人提供）：降低弱势群体风险中心（CRRVP）的总体目的是(a)推进弱势群体的生物行为健康科学，强调与脆弱相关的年龄（非常年轻和老年人），少数民族地位和较低的社会经济地位相关的问题；(b)减少疾病方面的差距；(c)通过向调查人员提供核心服务和资源来支持研究培训。该方案的工作将通过三个研究核心(a)多民族重点核心、(b)生物行为方法核心和(c)发展和传播核心来完成。CRRVP将赞助研究，以促进脆弱人群的生物行为健康科学，并在4年内资助新调查人员进行试点研究。CRRVP的科学是由生物行为和健康相关的生活质量框架组织的。该框架中的关键要素包括个人因素、环境因素、生理和心理变量、症状状态、功能状态、总体健康感知和生活质量。该方案支持的研究将(a)减少弱势群体的差距并促进健康的生活方式，(b)阐明导致症状、功能状况、感知健康状况和生活质量的潜在生理和心理机制，(c)试验减少症状、增强功能状况、感知健康状况和生活质量的干预措施。CRRVP支持的研究将具有很强的生物行为学取向，重点关注年轻人、老年人、少数民族和/或社会经济地位较低的人所经历的潜在/实际健康问题。此外，该方案将大力强调促进多族裔研究和通过研究缩小保健方面的差距。将与弱势群体有关的研究结合在一个中心的保护伞下，是对尚未探索的科学重叠部分的一种优势。具有不同学科专业知识的研究人员的相互作用将推动科学向新的方向发展。

DESCRIPTION (provided by applicant): The overall purpose of the Center for Reducing Risks in Vulnerable Populations (CRRVP) is to (a) advance the science of bio-behavioral health for vulnerable populations, emphasizing issues associated with vulnerability related age (very young and elderly), minority status, and lower socioeconomic status; (b) reduce disparities in disease/illness; and (c) support research training by providing core services and resources to investigators. The work of the CRRVP will be accomplished through three research cores (a) Multi-ethnic Emphasis Core, (b) Bio-behavioral Methods Core and (c) Development and Dissemination Core. The CRRVP will sponsor research to advance the science in bio-behavioral health for vulnerable populations and in the year four novice investigators will be funded to conduct pilot studies. The science of the CRRVP is organized by a bio-behavioral and health-related quality of life framework. Key elements in this framework include person (individual) factors, environmental factors, physiological and psychological variables, symptom status, functional status, general health perception, and quality of life. Studies supported by the CRRVP will (a) reduce disparity and promote healthy life styles for vulnerable populations, (b) elucidate underlying physiological and psychological mechanisms that contribute to symptoms, functional status, perceived health status and quality of life, (c) test interventions to minimize symptoms, enhance functional status, perceived health status and quality of life. The research supported by the CRRVP will have a strong bio-behavioral orientation with an emphasis on potential/real health problems experienced by people who are very young, elderly, minorities and/or lower socioeconomic status. In addition, the CRRVP will have a strong emphasis on facilitating multi-ethnic research and reducing disparity in health through research. The combining of research related to vulnerable populations under the umbrella of a single center is a strength to overlaps in the science that have not been explored. The interaction of investigators with expertise in diverse groups of subjects will move the science forward in new directions.