Core A--Administration and Biostatistics Core

生物统计学核心的主要目标是在每个研究的所有阶段与研究人员合作。我们将提供支持或负责方法学、统计学和计算机相关问题，包括研究设计、样本量计算和把握度分析、随机化时间表、数据收集工具、数据存储和检索、数据分析和手稿准备。生物统计学核心将负责确保每项研究设计充分，包括根据主要研究者样本陈述的假设，明确定义每项研究的主要和次要结局。协助确定具有特定I型和II型错误的样本量，当初始方法相对于可用动物池不可行时提供替代方法来检验假设，并为每项研究制定随机化时间表或采样方案。该核心帮助实施所有研究共同的质量控制措施，并为每个项目提供方法学支持，以开发所需的新分析技术，并根据需要协助数据分析和结果解释。

The biostatistics core's primary objective is to collaborate with investigators in each individual study throughout all phases of their research. We will provide support or be responsible for methodological, statistical and computer related issues including study design, sample size calculation and power analysis, randomization schedules, data collection instruments, data storage and retrieval, data analysis and manuscript preparation. The biostatistics core will be responsible for ensuring that each study design is adequate, including a clear definition of primary and secondary outcomes for each study, according to the hypothesis stated by the principal investigator's sample. There is assistance with sample size determination with specified Type I and Type II errors, provision of alternative methods to test hypothesis when the initial approach is not feasible relative to the pool of animals available and development of randomization schedules or sampling schemes for each study. The Core helps implement quality control measures common to all studies and provides methodological support to each project in developing new analytical techniques as needed and assisting in data analysis and interpretation of results as needed.