UCI Multidisciplinary Exercise Sciences Training Program

描述(由申请人提供)： 越来越多的人认识到，运动和不运动在许多疾病过程中发挥着重要作用。这项培训拨款提案的目标是为对运动科学感兴趣的医学博士和博士建立一个强大而丰富的研究培训环境。培训方案的基本方案主题是“综合/翻译”科学。该计划由三个核心小组组成：分子生理学核心小组、系统生理学核心小组和临床应用核心小组。这些核心的重点是骨骼肌、心血管和呼吸生理学、活动的神经生物学、康复和新陈代谢，因为这些领域代表了计划学院的重点，并代表了广泛正在进行的互动领域。综合/转换方法在运动科学中尤其重要，因为体育活动现在已知在人类健康中发挥着深远的作用。博士后研究员将通过正式的教学计划、研讨会、期刊俱乐部和正在进行的研究讨论与教师和其他实习生互动。在计划开始时，每个研究员将与执行委员会合作，选择主要和次要的研究重点，以反映运动科学中适当多样化的主题。这些重点将从基础科学核心中挑选出来。学员将熟悉动物和细胞模型系统以及最先进的人体性能测试方法，从而促进从这些系统到人类研究的转化，并最终转化为临床应用。对于后一个目标，加州大学欧文分校的人类行为实验室将发挥重要作用，因为它的资金专门用于支持环境中的翻译研究，以优化人类调查的安全性和质量。此外，我们还开发了一个创新的临床应用核心，这将显著增强这一培训拨款的翻译主题。这一拟议的培训计划旨在向博士后学员介绍新的学科，因为他们继续磨练在博士前几年掌握的技能和方法。对于博士后，该项目将吸引对成为独立研究人员感兴趣的个人。运动生理学不是ACGME认可的一个单独的专业或子专业；因此，在这个项目中寻求博士后培训的医学博士必须致力于学术事业。对于博士，该项目将最适合基础科学家，他们认为自己的学术生涯涉及临床互动，要么是通过直接的人体研究，要么是作为医学院的教员，那里的翻译研究活动可能得到鼓励。

DESCRIPTION (provided by applicant): There continues to be growing recognition that exercise and inactivity play important roles in many disease processes. The goal of this training grant proposal is to establish a strong and rich research training environment for M.D.s and Ph.D.s interested in exercise science. The underlying programmatic theme of the training program is "integrative/translational" science. The program consists of three core groups: the Molecular Physiology, Core Group, the Svstems Physiology Core Group, and the Clinical Applications Core Group. The emphasis of these cores is in skeletal muscle, cardiovascular and respiratory physiology, neurobiology of activity, rehabilitation, and metabolism given that these areas of research represent the focus of the Program Faculty, and represent areas of extensive on-going interactions. An integrated/translational approach is especially important in exercise science because of the profound role that physical activity is now known to play in human health. Postdoctoral fellows will interact with the faculty and other trainees through a formal didactic program, seminars, journal clubs, and research-in-progress discussions. At the beginning of the program each fellow will work with the Executive Committee to select a primary and secondary research emphasis designed to reflect an appropriate diversity of topics in exercise science. These emphases will be selected from the basic science cores. Trainees will become familiar with animal and cell model systems and state-of-the-art approaches to human performance testing, thereby facilitating the translation from these systems to human research and, ultimately to clinical applications. For this latter objective, the Human Performance Laboratory at the U.C. Irvine GCRC will play an important role as it is funded specifically to support translational research in an environment that optimizes the safety and quality of human investigation. Additionally, we have developed an innovative Clinical Applications Core that will significantly enhance the translational theme of this training grant. This proposed training program is designed to introduce postdoctoral trainees to new disciplines as they continue to hone skills and approaches mastered in the predoctoral years. For postdoctoral M.D.s, the program will attract individuals seriously interested in becoming independent investigators. Exercise physiology is not a separate ACGME-recognized specialty or subspecialty; consequently, M.D.s pursuing postdoctoral training in this program must be committed to academic careers. For Ph.D.s, the program will be best suited for basic scientists who see their academic careers involving clinical interaction either through direct human research or as members of faculties of medical schools where translational research activity is likely to be encouraged.