Training in Anti-Cancer Drug Development

描述(由申请人提供)：这是一份修订后的竞争续签申请，请求继续支持抗癌药物开发培训基金T32 CA09243，目前该基金已进入第25个年头。该培训计划由约翰·霍普金斯大学医学院药理学和分子科学系管理，其目标是为从事癌症相关药物开发领域的研究和教学工作的博士后和博士后学生做准备。 博士前培训为高素质的学生提供包括课程作业和研究在内的综合课程。基础科学的严谨核心课程在第一年进行，包括分子生物学、生物物理化学、生物有机机理、生物化学和细胞生物学。学生通过第二年必修的研究生药理学课程，以及通过选修课程、研讨会和期刊俱乐部，接受额外的指导和接触药理学和肿瘤学。博士前实习生在头两年选择一名教师导师和研究项目，然后将大部分时间投入到论文研究和获得书面和口头报告工作的经验。博士后实习生将大部分时间投入到研究中，这些研究更独立地进行，但在教师导师的适当指导下，为期一到三年。 该培训计划是跨学科的，汇集了来自7个系的教师：药理学和分子科学、肿瘤学、生物物理学和生物物理化学、化学、分子生物学和遗传学、泌尿学和环境健康科学。通过共同的研究兴趣、研讨会和期刊俱乐部，以及与学生有关的活动，如招聘周末、研究务虚会、师生晚宴和教学，促进了广泛的教职员工互动。 自1979年开始以来，这一培训计划已经支持了100多名博士后和博士后学员，他们中的大多数人进入了科学职业生涯，其中许多人在癌症研究领域担任了领导角色。

DESCRIPTION (provided by applicant): This is a revised competitive renewal application requesting continued support for the Anti-Cancer Drug Development training grant, T32 CA09243, presently in its 25th year. The training program is administered by the Department of Pharmacology & Molecular Sciences of the Johns Hopkins University School of Medicine, and its objective is to prepare pre- and postdoctoral students for research and teaching careers in the area of cancer-related drug development. Predoctoral training provides highly qualified students with an integrated curriculum including both course work and research. Rigorous core courses in the basic sciences are taken during the first year and include Molecular Biology, Biophysical Chemistry, Bio-organic Mechanisms, and Biochemistry and Cell Biology. Students receive additional instruction and exposure to pharmacology and oncology through the required Graduate Pharmacology course taken in the second year, and through elective courses, seminars, and journal clubs. Predoctoral trainees select a faculty preceptor and research project during their first two years, and devote most of their time after that to their thesis research and gaining experience with written and oral presentation of their work. Postdoctoral trainees devote most of their time to research carried out more independently, but with appropriate guidance from faculty mentors, for periods of one to three years. The training program is interdisciplinary and brings together faculty from 7 departments: Pharmacology & Molecular Sciences, Oncology, Biophysics & Biophysical Chemistry, Chemistry, Molecular Biology & Genetics, Urology, and Environmental Health Sciences. Extensive faculty interaction is promoted by common research interests, seminars and journal clubs, and by student-related activities such as recruiting weekends, research retreats, student-faculty dinners, and teaching. Since its beginning in 1979, this training program has supported over 100 pre- and postdoctoral trainees, most of whom have gone on to careers in science and many of whom have assumed leadership roles in the field of cancer research.