ROMP-Derived Oligomers for Faciliated Synthesis

描述（由申请人提供）：Materia, Inc.和堪萨斯大学之间的第一阶段小企业技术转移研究重点是开发高负荷、低聚试剂和清除剂，这些试剂和清除剂来自开环复分解聚合（ROMP），这是Materia， Inc.的几项核心复分解技术之一。第一阶段的具体目标集中在3个领域，都是利用ROM聚合，包括：(1)开发一系列高负荷，低聚清除剂；(2)开发一系列高负荷、低聚试剂；(3)开发一系列用于多步合成的高负荷低聚支撑。使用ROM聚合，这些低聚物将开发具有各种可调性质的，用于促进合成协议。I期研究产生的数据将用于II期研究，II期研究的重点是将这些低聚物商业化，用于促进药物发现的合成方案。总的来说，这些低聚物的发展将在几个新的研究领域开辟机会，包括整合合成和纯化，包括聚合物对聚合物反应，方便的高负荷液体分配，可溶性低聚物，以及高负荷试剂支持的合成方案。

DESCRIPTION (provided by applicant): This Phase I Small Business Technology Transfer study between Materia, Inc. and the University of Kansas is focused on the development of high-load, oligomeric reagents and scavenging agents derived from ring-opening metathesis polymerization (ROMP), 1 of several core metathesis technologies at Materia, Inc. The specific aims during Phase I focus on 3 areas, all utilizing ROM polymerization, including: (1) the development of an array of high-load, oligomeric scavenging agents; (2) the development of an array of high-load, oligomeric reagents; (3) the development of an array of high-load, oligomeric supports for multi-step synthesis. Using ROM polymerization, these oligomers will be developed with an assortment of tunable properties for use in facilitated synthetic protocols. The data generated from Phase I studies will be utilized in Phase II studies which are focused on the commercialization of these oligomers for use in facilitated synthetic protocols in drug discovery. Taken collectively, the development of these oligomers will open opportunities in several new areas of research involving integrating synthesis and purification, including polymer-on-polymer reactions, convenient liquid dispensing of high-load, soluble oligomers, and supported synthetic protocols enabled by high-load reagents.