Compositions for Prevention/Prophylactic Treatment of Poison Ivy Dermatitis

描述（由申请方提供）：本提案的长期目标旨在开发用于预防性治疗/预防敏感个体的毒葛接触性皮炎的新组合物。毒藤/毒橡树和另一种相关物种毒漆树是美国户外工作者职业危害的主要原因。目前市场上的大多数产品旨在在暴露于这些植物之前应用化学屏障或针对皮炎的对症治疗。本申请中提出的产品将针对从未暴露于毒葛的个体的治疗，并因此在这些个体中诱导耐受性（相当于免疫）和/或针对已经敏感的个体的预防性治疗，可能在每个季节之前使用单次注射。因此，本提案的目的是制备（合成）具有增强的物理和制剂特性的不同衍生物，在豚鼠动物模型中检测这些产品（或至少1种选定药物）的有效性，作为概念验证。这项工作的结果将构成II期申请的基础，该申请旨在优化处方、剂量和给药途径，以及开展稳定性、药代动力学和临床前毒理学/开发活动。该提案解决了一个主要的公共卫生问题，即接触性过敏性皮炎，并承诺开发一种有效的药物来解决这个问题。

DESCRIPTION (provided by applicant): The long term objectives of this proposal are aimed at the development of new composition(s) to be used for the prophylactic treatment/prevention of poison ivy contact dermatitis in sensitive individuals. Poison ivy/poison oak and another related species poison sumac are the main cause of occupational hazards for outdoor workers in the United States. Most of the products on the market today are aimed at applying a chemical barrier prior to being exposed to these plants or directed toward symptomatic treatment of the dermatitis. The products proposed in this application will be directed towards treatment of individuals who have never been exposed to poison ivy and therefore inducing tolerance in these individuals (equivalent to immunization) and/or towards prophylactic treatment of already sensitive individuals, perhaps using a single injection prior to each season. The aims, therefore of this proposal will be to prepare (synthesize) different derivatives with enhanced physical and formulation characteristics, testing of these products (or at least 1 selected agent) in the guinea pig animal model for efficacy as a proof of concept. The results of this work will form the basis for a Phase II application directed toward optimization of formulation, dosage and route of administration as well as carrying out stability, pharmacokinetics and preclinical toxicology/developmental activities. This proposal addresses a major public health problem, namely contact allergic dermatitis and promises the development of an effective agent to address this problem.