Phase behaviour and disruption in model bacterial cell envelopes

革兰氏阴性菌对抗生素的耐药性迅速增强，对健康构成重大威胁。这种抗性的一个关键方面是包围这些细菌的保护性外膜。科学地说，这个外膜很有趣，因为它可能代表不同的软物质状态。然而，从技术上讲，在相关的分子长度尺度上研究外膜是具有挑战性的。在这个项目中，我们将通过开发和描述模型系统来克服这一挑战，我们可以利用这些模型系统来改变和研究这种外膜的多个方面。这些模型系统接下来可以用作下一代抗生素的试验台。

Gram-negative bacteria are a major health threat due to their rapidly increasing resistance to antibiotics. A key aspect of this resistance is the protective outer membrane that surrounds these bacteria. Scientifically, this outer membrane is interesting because of the different soft matter states it may represent. Technically, however, it is challenging to investigate the outer membrane at the relevant molecular length scales. In this project, we will overcome this challenge by developing and characterising model systems with which we can vary and study multiple aspects of this outer membrane. These model systems can next be used as a testbed for next-generation antibiotics.