Vascular Surgery: Research Training in Vascular Biology

描述(由申请人提供)： 血管生物学的研究进展很快。然而，与此同时，内科科学家承担着越来越多的临床责任，为了满足报销要求，他们必须亲自承担这些责任。此外，随着人口老龄化，血管疾病患者的数量也在增加。虽然血管生物学基础研究的时间越来越少，推动该学科发展的内科科学家也越来越少，但这笔培训拨款试图通过培养下一代外科/内科科学家来解决这一问题。 Jobst血管实验室在血管生物学基础研究方面与基础科学家的合作研究有着悠久的历史。最近，一个综合性的心血管中心已经被密歇根大学的试剂批准。该中心将本地化所有涉及心血管疾病患者护理和治疗的主要服务，包括血管外科、血管内科、心脏外科、心脏病学和介入血管造影术。这个耗资1.86亿美元的设施将于2007年开放。一个类似的研究设施，包括40,000平方英尺的实验室空间，正在计划中，这将允许集中那些参与心血管研究的科学家。随着心血管中心的开花结果，目前关于建立以Jobst血管实验室为中心的血管疾病培训赠款的提议是及时的。 这项建议涉及来自不同学科的多个教员，包括血管外科、血管内科、心脏病学、血液学、人类遗传学、微生物学/免疫学、分子医学/遗传学、病理学、放射学和实验动物医学部。除了受训人员与项目学院的个别科学家密切合作外，该提案还有一个说教部分。该计划的共同主线是强调血管壁生物学和血管病理学的基础研究，最终目标是培养下一代学术血管科学的领导者。

DESCRIPTION (provided by applicant): Research in vascular biology is rapidly progressing. At the same time, however, physician scientists have increasing clinical responsibilities which they must personally attend to in order to fulfill reimbursement requirements. Additionally, with the aging of the population, the number of patients with vascular disease is increasing. While there is less time for basic research in vascular biology and fewer physician scientists are advancing the discipline, this training grant seeks to address this problem by preparing the next generation of surgeon/physician scientists. The Jobst Vascular laboratory has a long history of collaborative research with basic scientists in the investigation of basic research in vascular biology. Recently, a comprehensive Cardiovascular Center has been approved by the Reagents of the University of Michigan. This Center will localize all primary services involved in the care and treatment of patients with cardiovascular disease including Vascular Surgery, Vascular Medicine, Cardiac Surgery, Cardiology, and Interventional Angiography. This $186,000,000 facility will open in 2007. A similar research facility, including 40,000 square feet of laboratory space, is planned which will allow centralization of those scientists involved in cardiovascular research. With the Cardiovascular Center coming to fruition, the present proposal to establish a training grant proposal in vascular diseases centered in the Jobst Vascular laboratory is timely. This proposal involves a number of faculty from various disciplines including Vascular Surgery, Vascular Medicine, Cardiology, Hematology, Human Genetics, Microbiology/Immunology, Molecular Medicine/Genetics, Pathology, Radiology, and the Unit for Laboratory Animal Medicine. There is a didactic component to the proposal, in addition to the trainee working intensely with individual scientists from the Program Faculty. The common thread in this program is the emphasis on the basic study of vessel wall biology and vascular pathology with the ultimate goal to produce the next generation of leaders in academic vascular sciences.