Training in Synaptic Neurobiology

描述(由申请人提供) 综合运用生物化学、分子生物学、 细胞生物学、解剖学和生理学是促进我们理解的中心 突触的形成、组织和功能。建议的目的是 该计划旨在提供侧重于突触的博士后和博士后培训 神经生物学。我们的培训战略得益于它能够强调 需要跨学科方法的一组特定的当前问题，而 仍然保持着广泛的培训经验和接触广泛的 各种智力工具。这项研究是为 了解--并有望缓解--众多神经疾病。这个 培训将由7名分子、细胞和 综合神经科学(MCIN)计划。教职员工来自四个国家 两所学院的系。这些教职员工和其他14名教职员工 组织并教授核心神经生物学课程，提供讲座， 文学、实验室和讨论课程。在该计划中有 能够将这一基本知识应用于实际治疗的个人 神经疾病，通过他们作为临床科学家的联合任命 在科罗拉多州立大学兽医教学医院。2000-2001年间， 15名博士后和20名博士后在 培训学院的实验室。这些受训人员得到了 个人研究补助金、博士后和研究生奖学金，以及 来自MCIN项目的研究生助教奖学金。大多数博士后实习生 拥有传统学科的学位，并通过以下方式招聘 参与部门或通过MCIN计划。所有的博士后 受训者直接与他们的导师联系，没有被招募。 该计划将允许我们招收4名博士后 培训并支持2名博士后学员参加 涉及多个实验室的跨学科项目，最多3个 好几年了。这些新成员对于加强互动将是重要的 并将为学员提供一个独特的机会来 获得在当今研究中取得成功所需的多学科技能 环境。所有受训人员将有机会接触到现代细胞和分子 生物设施，包括计算机增强的光、共焦和电子 显微镜(中电压)、电生理学和 光/荧光显微镜设备、大分子合成和 测序设施、基因克隆和细胞转基因实验室，以及 高质量的实验动物资源设施。

DESCRIPTION (provided by applicant) Integrated investigations using methods from biochemistry, molecular biology, cell biology, anatomy and physiology are central to advancing our understanding of synapse formation, organization and function. The purpose of the proposed program is to provide postdoctoral and predoctoral training focused in synaptic neurobiology. Our strategy for training gains from its ability to emphasize a specific set of current issues that require an interdisciplinary approach while still maintaining a breadth of training experience and exposure to a wide variety of intellectual tools. This research is the foundation for understanding - and hopefully alleviating - numerous neurological diseases. The training will be provided by 7 faculty members of the Molecular, Cellular and Integrative Neuroscience (MCIN) Program. The faculty members come from four departments in two colleges. These faculty, along with 14 others, have organized and teach a core neurobiology curriculum offering lecture, literature, laboratory and discussion courses. Within the program are individuals who can apply this fundamental knowledge in actual treatment of neurological disorders, through their joint appointments as clinical scientists at the Colorado State University Veterinary Teaching Hospital. In 2000 - 2001, 15 predoctoral and 20 postdoctoral students received training in the laboratories of the training faculty. These trainees were supported from individual research grants, postdoctoral and graduate fellowships, and by graduate assistantships from the MCIN Program. Most of the predoctoral trainees have degrees in traditional disciplines and were recruited either through participating departments or through the MCIN program. All of the postdoctoral trainees initiated contact with their mentors directly and were not recruited. The program described in this proposal would allow us to recruit 4 postdoctoral trainees and support 2 predoctoral students to participate in cross-disciplinary projects involving more than one laboratory for up to 3 years. These recruits will be important for strengthening the interactions between laboratories and will provide the trainees with a unique opportunity to acquire the multidisciplinary skills needed for success in today's research environment. All trainees will have access to modern cell and molecular biological facilities including computer enhanced light, confocal and electron microscopy (intermediate voltage), combined electrophysiology and light/fluorescence microscopy equipment, macromolecular synthesis and sequencing facilities, gene cloning and cell transfection laboratories, and a high quality lab animal resource facility.