Spectro-temporal and binaural response properties

描述(申请人提供)：下丘中央核(ICC)在频谱、时间和双耳信息的声学分析中起着关键作用。它的层状组织和高度有序的汇聚传入的马赛克表明，在向听觉丘脑的过渡过程中，这种声学信息的巩固起着关键作用。我们假设，频谱-时间和双耳感受场特征的分布布局将在中央核有系统地排列，其方式反映了神经传入和局部丘脑回路的模式。在这项研究中，我们建议描述中央核内光谱-时间感受野(STRF)偏好的分布组织。结构宽带噪声的STRF分析将被用来表征神经元的偏好，并系统地将这些与传统纯音刺激的测量相关联。提出了单单位记录实验，以表征STRF偏好的微观组织，并确定感受野遗传/构建在脑干向中央核转变过程中的作用。然后，ICC的分布式映射将允许我们同时表征三维结构中光谱、时间和双耳接受场偏好的全球组织。同时进行的解剖学研究将显示两个平行记录轨道的地形位置以及它们各自向内侧膝状体的投射。这些预期的发现将为理解复杂听觉刺激中频谱-时间和双耳特征的声学分析提供一个框架，然后我们可以将其与脑干输入的组织层次、局部电路和模块化组织联系起来。

DESCRIPTION (provided by applicant): The central nucleus of the inferior colliculus (ICC) plays a key role in the acoustic analysis of spectral, temporal and binaural information. Its laminar organization and highly ordered mosaic of converging afferents suggests a critical role in consolidating this acoustic information in the transition to the auditory thalamus. We hypothesize that the distributed layout of spectro-temporal and binaural receptive field features will be systematically ordered in the central nucleus in a manner that reflects the patterns of innervating afferents and the local collicular circuitry. In this study, we propose to characterize the distributed organization of spectro-temporal receptive field (STRF) preferences within the central nucleus. STRF analysis with structured broadband noise will be used to characterize neuronal preferences and to systematically relate these to measurements from conventional pure-tone stimuli. Single unit recording experiments are proposed to characterize the micro-organization of STRF preferences and to identify the roles of receptive field inheritance / construction in the transformation from the brainstem to the central nucleus. Distributed mapping of the ICC will then allow us to simultaneously characterize the global-organization of spectral, temporal and binaural receptive field preferences within the three dimensional structure. Concurrent anatomic studies will show the topographic position of two parallel recording tracks and their respective projections to medial geniculate body. The expected findings will provide a framework for understanding the acoustic analysis of spectro-temporal and binaural features in complex auditory stimuli, which we can then relate to the organizational hierarchy of brainstem inputs, local circuitry, and modular organization.