RETROVIRUS RESEARCH LEADERSHIP CORE: HIV/AIDS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。逆转录病毒研究中心是一个研究艾滋病毒/艾滋病和其他逆转录病毒的多学科研究中心。其总体目标是促进和便利波多黎各的艾滋病毒/艾滋病和其他逆转录病毒研究。该中心由中央加勒比大学及其位于波多黎各巴亚蒙卫生区的旗舰医疗机构赞助。逆转录病毒中心将艾滋病毒感染的研究作为一个多学科的研究领域，其中需要将临床特征、免疫学和病毒学因素以及心理和行为参数整合到一个连贯的研究策略中。该中心凝聚了多学科研究人员的联盟，他们的兴趣是根据问题的生态学观点描述和理解在艾滋病毒感染的进展和/或表现中发挥作用的关键因素。在这项提案中，我们将中心的结构安排在三个相互交错的核心设施中，这将为开展我们的研究人员非常感兴趣的几项试验性研究提供支持。领导核心的作用是协调和促进艾滋病毒/艾滋病研究的智力刺激环境，在产生假设驱动的研究方面发挥积极作用。领导核心的隐含目标是在与人类疾病相关的三个轴上促进与艾滋病毒相关的研究，包括生物学、行为和心理社会维度。它将为研究波多黎各人口中艾滋病毒疾病的多方面问题制定指导方针。我们中心的这一多学科愿景是对国家卫生研究院在研究疾病复杂性方面所扮演的角色的回应。我们的患者群体相当独特，因为他们大多起源于西班牙裔，70%-80%的人感染艾滋病毒直接或间接与药物滥用行为有关。逆转录病毒中心在继续这一患者群体的研究议程方面发挥重要作用，最终目标是减少艾滋病毒流行病在该岛的传播性质。领导核心将通过其两个主要核心设施：艾滋病毒/艾滋病数据核心和实验室核心，提供行政基础设施和后勤支持研究活动。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Retrovirus Research Center is a multidisciplinary research center for the study of HIV/AIDS and other retroviruses. Its general goal is to promote and facilitate HIV/AIDS and other retrovirus research in Puerto Rico. The center is sponsored by the Universidad Central del Caribe and its flagship health care facility located in the Bayamon Health Region of Puerto Rico. The Retrovirus Center promotes the study of HIV infection as a multidisciplinary research arena in which the clinical features, immunological, and virological elements, and the psychological and behavioral parameters need to be integrated into a coherent research strategy. The center agglutinates a coalition of multidisciplinary researchers whose interest is to describe and understand key elements that play a role in the progression and/or expression of HIV infection according to an ecological view of the problem. In this proposal we have organized the structure of the Center in three interlacing core facilities, which will provide support for the development of several pilot studies of great interest to our investigators. The role of the Leadership Core is to coordinate and facilitate an intellectually stimulating environment for HIV/AIDS research by playing a proactive role in generating hypothesis-driven studies. It is the implicit aim of the leadership core to promote HIV-related research in the three axis relevant to human disease including the biological, the behavioral, and the psychosocial dimensions. It will establish the guidelines for the study of the multidimensional aspects of HIV disease in the Puerto Rican population. This multidisciplinary vision of our center is responsive to the vision of the National Institutes of Health their role of studying the complexity of diseases. Our patient population is rather unique in that they are mostly Hispanic in origin and between 70-80% have HIV infection directly or indirectly related to substance abuse practices. The Retrovirus Center has an important role in continuing the research agenda with this patient population with the ultimate goal of diminishing the spreading nature of the HIV epidemic in the island. The Leadership Core will provide an administrative infrastructure and logistic to support research activities through its main two core facilities: The HIV/AIDS Data Core and the Laboratory Core.