CANCER RESEARCH UNIT

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 UCC在培训未被充分代表的少数民族和进行基础生物医学研究方面有着成功的历史。我们首次提出了一个专注于癌症研究的以疾病为导向的中心，该中心具有明显的潜力来支持促进转化研究的机构研究议程。目前，UCC癌症研究人员致力于饮食化合物作为乳腺癌预防药物的基础和翻译研究，开发乳腺癌的新型治疗药物，并鉴定转移性乳腺癌的分子标志物。这项研究计划预计将由拟议的癌症中心进行培育和扩展。 拟议的癌症研究股的目标是通过培训下一代少数族裔癌症研究人员，建设加州大学癌症研究中心的癌症研究能力，并增加少数族裔参与癌症研究。为了实现这一目标，将实现以下具体目标：1)扩大UCC进行癌症研究的基础设施；2)增加UCC的癌症研究人员数量；3)在UCC发展转化型和临床癌症研究；4)建立癌症研究系列研讨会，并继续癌症小组会议和期刊俱乐部；5)教育社区关于癌症预防/早期检测；6)支持初级教员的试点项目。 该中心将由一名高级研究人员领导，将组织成三个主要领域：1)在细胞和小鼠模型中测试新型癌症疗法的有效性，2)癌症病理的基因组和蛋白质阵列分析，3)建立主要来自西班牙裔患者的癌症组织储存库。癌症研究中心的目标是促进癌症预防和治疗方面的转化研究。我们将与RCMI/SRDU合作，招聘两名教员，而癌症研究中心将招聘一名博士后实习生和一名技术员，以支持教员的研究。这将加强和启动我们的最终目标，即创建一个活跃的癌症研究人员核心。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. UCC has a successful history of training underrepresented minorities and conducting basic biomedical research. For the first time, we propose a disease-oriented center focused on cancer research that has clear potential to support the institutional research agenda of fostering translational research. Currently, UCC cancer investigators pursue basic and translational research on dietary compounds as breast cancer preventives, development of novel therapeutic agents for breast cancer, and identification of molecular markers for metastatic breast cancer. This research program is expected to be nurtured and expanded by the proposed cancer center. The OBJECTIVE of the proposed Cancer Research Unit is to build cancer research capacity at UCC and increase minority participation in cancer research by training the next generation of minority cancer researchers. To achieve this objective, the following SPECIFIC AIMS will be carried out: 1) Expand the infrastructure to conduct cancer research at UCC; 2) Increase the number of cancer researchers at UCC; 3) Develop translational and clinical cancer research at UCC; 4) Establish a seminar series on cancer research and continuation of the cancer group meetings and journal club; 5) Educate the community about cancer prevention/early testing; 6) Support a Pilot Project from a junior faculty member. The center will be led by a senior researcher and will be organized into three main areas: 1) Testing the efficacy of novel cancer therapeutics in cell and mouse models, 2) genomic and protein array analysis of cancer pathology, 3) establishment of a cancer tissue repository from patients of mainly Hispanic origin. The GOAL of the Cancer Research Center is to facilitate translational research in the prevention and treatment of cancer. In collaboration with the RCMI/SRDU, we will recruit two faculty members while the Cancer Research Center will recruit one postdoctoral trainee and one technician to support the research of the faculty. This will reinforce and jumpstart our ultimate goal of creating a nucleus of active cancer researchers.