Amygdala and Prefrontal Control of the Rhinal Cortices

描述（申请人提供）：鼻皮层在陈述性记忆中起着至关重要的作用，是海马体和皮层之间冲动传输的主要途径。然而，生理学数据表明，鼻腔皮层不是被动的中继站；新皮层和内嗅输入传输的概率很低。本研究的目的是评估是否以及如何解除限制脉冲传播通过鼻皮层的抑制机制。一种可能性是，这可能发生在情绪唤起的情况下，此时陈述性记忆通常会增强。杏仁核和内侧前额叶皮层都对鼻皮质有很大的影响，两者都与情绪促进记忆有关。麻醉猫体内的细胞外和细胞内记录将评估杏仁核和内侧前额叶皮层促进通过鼻皮质的冲动转移的能力。

DESCRIPTION (provided by applicant): The rhinal cortices play a critical role in declarative memory and constitute the main route for impulse traffic between the hippocampus and cortex. However, physiological data suggests that the rhinal cortices are not a passive relay station; neocortical and entorhinal inputs are transmitted with a low probability. The goal of the research described here is to assess whether and how the inhibitory mechanisms that limit impulse propagation through the rhinal cortices are lifted. One possibility is that this could occur during emotionally arousing conditions, when declarative memory is generally enhanced. Both the amygdala and medial prefrontal cortex project heavily to the rhinal cortices, and both are implicated in the facilitation of memory by emotions. Both extracellular and intracellular recordings in vivo in anesthetized cats will assess the ability of the amygdala and medial prefrontal cortex to facilitate impulse transfer through the rhinal cortices.