PEPTIDE BIOCOMPATIBLE POLYMER MACROMOLECULAR COMPLEXES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。由合成的生物相容性聚合物和生物活性肽/分子组成的大分子系统由于在药物传递和组织工程中的应用而受到关注。正在开发用于此类应用的大分子系统是通过将合成聚合物与寡肽和/或生物活性分子共价连接制备的。如果这样的大分子体系可以利用非共价相互作用力作为偶联方法来制备，这是令人感兴趣的。最近的研究导致了制备、表征和仔细阐明形成稳定的肽/生物相容性聚合物复合物所必需的非共价（主要是疏水）力的方法的发展。基于这些研究，提出的研究可分为以下两部分：开发用于组织工程和药物输送的非共价共轭肽水凝胶体系。用于生物活性分子/肽药物递送的可生物降解反胶束的开发。具体来说，将演示以下内容：水凝胶/肽非共价加合物在肽药物传递和组织工程中的适用性。可生物降解的反胶束在药物输送中的适用性。我们研究的总体和首要目标是开发生物活性分子和生物相容性聚合物的非共价加合物，用于组织工程和药物输送系统。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Macromolecular systems composed of synthetic biocompatible polymers and bioactive peptides/molecules have received attention because of application in drug delivery and tissue engineering. The macromolecular systems being developed for such applications have been prepared by covalent linking of the synthetic polymer with the oligopeptide and/or bioactive molecules. It is of interest if such macromolecular systems may be prepared utilizing non-covalent forces of interaction(s) as the method of conjugation. Recent studies have led to the development of methods to prepare, characterize and carefully elucidate non-covalent (mainly hydrophobic) forces necessary for the formation of stable peptide/biocompatible polymer complexes. Based on these studies, the proposed research may be divided into two parts as follows: ¿Development of hydrogels systems with non-covalently conjugated peptides for tissue engineering and drug delivery. ¿ Development of biodegradable reverse micelles for bioactive molecule/peptide drug delivery. Specifically the following will be demonstrated: ¿The applicability of hydrogel/peptide non-covalent adducts for peptide drug delivery and tissue engineering. ¿Applicability of biodegradable reverse micelles for drug delivery. The overall and overarching goal of our studies is the development of non-covalent adducts of a bioactive molecule and biocompatible polymer for application in tissue engineering and drug delivery systems.