Fractures and bisphosphonates: reviving osteoporosis treatment uptake by identifying the genetic, material, and microstructural risk factors of atypical femur fractures.

非典型股骨骨折（AFF）是罕见的，但灾难性的并发症，抗骨质疏松症治疗包括双磷酸盐。我们将通过确定患者骨骼结构和质量的变化，以及确定增加这些骨折风险的基因来识别有AFF风险的患者。通过这种方式，廉价而有效的抗吸收治疗可以针对AFF风险最低的患者，并为风险最高的患者提供替代治疗。

Atypical femoral fractures (AFF) are uncommon, but catastrophic, complications of antiresorptive osteoporosis treatments including bisphosphonates. We will identify patients at risk of AFF by determining changes in their bone structure and quality, and identifying genes that increase the risk of these fractures. In this way, cheap and effective antiresorptive treatments can be targeted to patients at the lowest risk of AFF and alternative treatments to those at highest risk.