Predicting Friction of Total Joint Replacement Bearings

虽然全关节置换术的磨损一直是许多临床和临床前研究的焦点，但在轴承部件滑动界面处的摩擦并没有得到同样的关注。随着骨科技术的进步，需要更好地预测摩擦并了解其对器械寿命的系统性影响。由于新材料和设计的使用，承载表面的摩擦与模块组件和骨固定之间的种植体界面变得更加相关，这两者都与临床失败有关。尽管五十年来全关节置换术的临床前模拟，但在临床前测试方法中，尚不存在准确预测摩擦的框架。该项目的目的是产生一个计算框架，用于预测关节更换轴承内的摩擦和磨损，并同时进行实验验证。从表面尺度混合润滑摩擦模型开始，这将扩展到产生关节更换轴承的多尺度计算模拟。该项目将超越现有的现象学磨损和润滑模型，提供一种新的多尺度混合润滑（含弹性流体动力润滑和接触力学）摩擦和磨损模型。

Whilst the wear of total joint replacements has been the focus of many clinical and pre-clinical studies, the friction acting at the sliding interface of the bearing component has not received the same attention. As orthopaedic technologies progress there is a need to better predict friction and understand its systemic effects on device longevity. Due to the use of new materials and designs, friction at the bearing surfaces has become more relevant for implant interfaces between modular components and the fixation to bone, both of which are implicated in clinical failure. Despite five decades of pre-clinical simulation of total joint replacements, a framework for the accurate prediction of friction when subjected to established pre-clinical testing methodologies does not exist. The aim of this project is to produce a computational framework for predicting friction and wear within a joint replacement bearing with concurrent experimental validation. Starting with a surface-scale mixed lubrication friction model, this will be extended to produce a multiscale computational simulation of the joint replacement bearing. This project will go beyond current phenomenological wear and lubrication models to provide a novel multiscale mixed lubrication (with elastohydrodynamic lubrication and contact mechanics) model of friction and wear.