Autonomous Microscale Manufacture of Oral Solid Dosage Forms

该项目将成为Made Smarter Innovation - Digital Medicines Manufacturing Research Centre（DM 2）的一部分，重点是创建一个独特的自主微型药品生产和测试系统，以选择配方和工艺，从而获得具有所需关键质量属性（CQA）的稳定产品。该平台将为解决复杂的、多长度和多维的材料-工艺-产品-性能关系进行基础研究。集成工业数字技术（IDT）将降低风险并加速药品生产，大大减少开发时间和原材料/溶剂，同时通过自我优化配方和工艺条件实现CQA目标。这将与支持行业合作伙伴共同开发，重点是1）片剂（通过直接压片）和2）胶囊（通过粉末填充）。

This project will be part of the Made Smarter Innovation - Digital Medicines Manufacturing Research Centre (DM2) with a focus on creating a unique autonomous microscale drug product manufacturing and testing system to select formulation and process that result in a stable product with desired critical quality attributes (CQAs). The platform will perform fundamental research into resolving the complex, multi-length and -dimensional material-process-product-performance relationship. Integrating industrial digital technologies (IDTs) will de-risk and accelerate drug product manufacture, dramatically reducing development time and raw material/solvents, whilst achieving CQA objectives by self-optimised formulation and process conditions. This will be co-developed with supporting industry partners focussing on 1) tablets (via direct compression) and 2) capsule (via powder fill).