ERP Studies of Dual Processes in Recognition Memory

描述（由申请人提供）：拟议研究的目的是 了解人类认知记忆的神经认知过程。 识别是由对一般信息敏感的过程支持的。 熟悉的刺激，以及通过过程，使回忆的 具体信息。行为研究表明，这些过程可能是 通过操纵不同影响回忆的变量来分离 和熟悉程度，但潜在的大脑过程的特征 还有待于可靠地区分。根据初步结果，建议 研究调查了这样一个假设，即回忆和熟悉可以 事件相关脑电位（ERP）。早期（300-500 ms） 额叶ERP效应受刺激熟悉度的调节，而 （400-800 ms）顶叶ERP效应与回忆有关。总体目标 的建议研究是为了更好地说明之间的关系， 假设ERP熟悉和回忆效应，当代理论， 熟悉和回忆，以及行为识别记忆表现。 第一个具体的目的是描绘时间之间的对应关系， 假设的ERP熟悉和回忆效应以及行为 识别记忆性能第二个具体目标是 电生理学复制几种行为分离， 回忆和熟悉，这是以前报道过的。第三 一个具体的目标是使用ERP来检查经验现象，这些现象是核心， 关于再认记忆的认知理论本研究 将促进我们对人类记忆过程的理解， 在认知和神经层面都是如此。我们对大脑机制的理解 记忆的能力将通过描述时间和解剖结构来提高 这些过程的可分离性。我们对认知过程的理解 将通过建立以下措施来增强记忆和熟悉程度 脑电活动可以可靠地区分这些过程， 通过操纵已知会影响识别的心理变量， 观察这些变量如何不同地影响电生理 回忆和熟悉程度的测量。未来的研究可以应用这些 与正常人相关的记忆障碍的研究方法 衰老、精神障碍和神经损伤。

DESCRIPTION (provided by applicant): The purpose of the proposed research is to understand the neurocognitive processes that underlie human recognition memory. Recognition is supported by processes that are sensitive to the general familiarity of stimuli as well as by processes enabling the recollection of specific information. Behavioral research suggests that these processes can be dissociated by manipulating variables that differentially affect recollection and familiarity, but the characteristics of the underlying brain processes have yet to be reliably differentiated. Based on preliminary results, the proposed research investigates the hypothesis that recollection and familiarity can be differentiated with event-related brain potentials (ERPs). Early (300-500 ms) frontal ERP effects are modulated by stimulus familiarity, whereas later (400-800 ms) parietal ERP effects are related to recollection. The general aim of the proposed research is to better specify the relationship between the hypothesized ERP familiarity and recollection effects, contemporary theories of familiarity and recollection, and behavioral recognition memory performance. The first specific aim is to delineate the temporal correspondence between the hypothesized ERP familiarity and recollection effects and behavioral recognition memory performance. The second specific aim is to electrophysiologically replicate several behavioral dissociations between recollection and familiarity that have been previously reported. The third specific aim is to use ERPs to examine empirical phenomena that are central to current cognitive theorizing about recognition memory. The present research will advance our understanding of the processes that underlie human memory at both the cognitive and neural level. Our understanding of the brain mechanisms of memory will be advanced by characterizing the timing and anatomical separability of these processes. Our understanding of the cognitive processes of recollection and familiarity will be enhanced by establishing measures of brain electrical activity that reliably differentiate between these processes, by manipulating psychological variables known to affect recognition, and by observing how these variables differentially affect the electrophysiological measures of recollection and familiarity. Future studies can apply these methods to the investigation of memory impairments associated with normal aging, psychiatric disorders, and neurological damage.