DOCTORAL STUDIES IN MOLECULAR BIOPHYSICS

描述(由申请人提供)：卫斯理大学分子生物物理学项目的三(3)名毕业生实习生奖学金申请继续资助。卫斯理分子生物物理学是该大学研究生部的一个跨学科、跨部门的项目，学生通过研究生课程、每周一次的期刊俱乐部、年度务虚会、研讨会、小组会议、研讨会、论文研究和教学见习来攻读博士学位。它强调在可行的情况下，教员研究小组之间的合作项目，以及实验者和理论家之间的互动。科学伦理以及科学的历史和知识基础在课程中占有重要地位。目前和拟议的计划涉及化学、分子生物学和生物化学(MBB)和物理系的教职员工，生物系的咨询和未来可能的参与。化学方面的教员有Anne M.Baranger(生物和BID有机化学；RNA折叠和RNA-蛋白质络合物形成)、David L.Beveridge(理论和计算生物物理学)、Philip H.Bolton(核磁共振光谱；蛋白质和核酸)、Rex F.Pratt(酶化学；酶在合成中)和Rina Russu(核磁共振光谱、DNA动力学和蛋白质-DNA相互作用)。来自MBB的参与人员是Ishita Mukerji(紫外共振拉曼光谱；蛋白质-DNA相互作用；蛋白质-蛋白质相互作用)和Manju Hingorani(DNA酶的速率过程和酶)。来自物理系的参与教员是Roderick V.Jensen(非线性动力学、计算神经科学、生物信息学)。所有参与的教员都从外部资金来源或未决的提案中获得了对他们的研究项目的重要独立支持。卫斯理大学是一所规模较小、高度挑剔的大学，在本科生水平上强调文科和理科，并设有理科博士课程。作为我们研究生课程的补充，本科生专攻分子生物物理学。在第三次更新期间的课程和教学举措将产生核心课程的新版本，分子生物物理学导论和化学生物学、高级生物化学、DNA代谢酶的动力学机制和结构生物学的新课程。

DESCRIPTION (provided by applicant): Continuation of support is requested for three (3) graduate trainee fellowships in the Molecular Biophysics Program at Wesleyan University. Molecular Biophysics at Wesleyan is an interdisciplinary, interdepartmental program in the Graduate Division of the University in which students pursue doctoral studies via graduate courses, a weekly journal club, an annual retreat, workshops, group meetings, seminars, dissertation research and teaching apprenticeships. The emphasizes collaborative projects among faculty research groups where feasible and interactions between experimentalists and theoreticians. Scientific ethics and the historical and intellectual foundations science figure significantly in the curriculum. The current and proposed program involves faculty of the Departments of Chemistry, Molecular Biology and Biochemistry (MBB), and Physics, with consultation and potential future participation of the Biology department. The participating faculty from Chemistry are Anne M. Baranger (Biological and BiD-organic Chemistry; RNA Folding and RNA-Protein Complex Formation), David L. Beveridge (Theoretical and Computational Bio-physics), Philip H. Bolton (NMR Spectroscopy; Proteins and Nucleic Acids), Rex F. Pratt (Chemistry of Enzymes; Enzymes in Synthesis), and [rina Russu (NMR Spectroscopy, DNA dynamics and Protein-DNA Interactions). The participating faculty from MBB are Ishita Mukerji (UV Resonance Raman Spectroscopy; Protein-DNA Interactions; Protein-Protein Interactions) and Manju Hingorani (Rate Processes and Enzymology of DNA Enzymes). The participating faculty member from the Physics Department is Roderick V. Jensen (Non-linear Dynamics, Computational Neuroscience, Bio-informatics). Participating faculty all have significant independent support for their research programs from extramural funding sources or proposals pending. Wesleyan University is a small, highly selective university emphasizing the liberal arts and sciences at the undergraduate level with Ph.D. programs in the sciences. An undergraduate concentration in Molecular Biophysics has been developed as a complement to our graduate program. Curricular and pedagogical initiatives in this third renewal period will produce a new version of a core course, Introduction to Molecular Biophysics and new courses in Chemical Biology, Advanced Biochemistry, and Kinetic mechanisms and Structural Biology of DNA metabolic enzymes.