Cooperative Center for Research in Reproduction

描述(由申请人提供)：宾夕法尼亚州立大学(PSU)和梅哈里医学院(MMC)的合作伙伴关系建议在MMC建立一个生殖研究合作中心。该提案涉及两个目标。首先，该中心将在以妇科内分泌学为重点的主题领域进行科学合理的临床相关研究。具体地说，研究开发核心将研究：1)性类固醇激素作为黑人女性骨密度得分决定因素的作用，2)口服避孕药对子宫肌瘤生长的影响，3)二甲双胍和生活方式因素在改善高雄激素血症及其相关症状方面的有效性和安全性。这些研究将产生不同种族的知识和比较。其次，通过开发少数族裔发起的研究提案，与经验丰富的研究人员组成的研究密集型机构网络进行合作和指导，以最终在MMC建立独立的临床研究团队的能力，加强历史上由黑人组成的医学院的研究基础设施的迫切需要将得到促进。此外，MMC将加强核心研究支持资源。

DESCRIPTION (provided by applicant): The collaborative partnership of Pennsylvania State University (PSU) and Meharry Medical College (MMC) proposes the development of a Cooperative Center for Research in Reproduction at MMC. The proposal addresses two goals. First, the Center will conduct scientifically sound, clinically relevant research in a thematically focused area of gynecologic endocrinology. Specifically, the research development core will study: 1) the role of sex steroid hormones as determinants of bone mineral density score in Black females, 2) the influence of oral contraceptives on the growth of uterine fibroids, and 3) the efficacy and safety of metformin and lifestyle factors in the amelioration of hyperandrogenemia and its associated symptomatology. These studies will generate knowledge and comparisons across race. Secondly, the compelling need to strengthen research infrastructure at a historically Black medical school through development of minority-initiated research proposals, collaboration and mentorship with a research intensive institutional network of experienced investigators, toward the eventual capacity to build an independent clinical research team at MMC will be facilitated. Additionally, core research support resources will be enhanced at MMC.