PILOT AND FEASIBILITY PROGRAM

马萨诸塞大学医学院DERC的试点和可行性(P&F)计划有三个主要目标。1)为准备从事糖尿病和内分泌学相关研究的新研究人员提供启动资金。2)为现有的研究人员提供机会，以开发可能加强糖尿病相关研究的新技术。3)使其他领域的现有调查人员能够发起 在与糖尿病相关的领域进行研究。与这些目标相关的是提供支持和指导，使P&F计划获奖者能够成功竞争外部资金，使他们能够继续活跃在与糖尿病相关的研究中。 自从马萨诸塞大学医学院DERC于1983年启动以来，我们收到了与每个目标相关的建议。共有41项由P&F计划资助的研究提案已经完成。由P&F计划资助的另外八个研究项目仍在进行中。超过四分之三的提案摘要导致邀请提交完整的提案。已完成的提案中约有三分之一获得了资金。自上次竞争性续签以来，已资助和/或完成了22个P&F提案。17项P&F研究的调查人员(不包括2004年资助的5项)从外部机构获得了30笔赠款，本年度的直接费用总额超过350万美元。 自获得P&F奖以来，DERC资助的P&F调查人员已经出版了大约57份手稿。DERC特别高兴的是，至少有七名受过其他领域培训的研究人员(钱伯斯、连、陈、萨格斯特罗姆、科恩菲尔德、蒂森鲍姆和劳森)能够承担与糖尿病相关的研究项目。作为马萨诸塞大学医学院DERC竞争性更新的一部分，试点和可行性(P&F)计划的设计非常类似于自 该计划的开始。

The Pilot and Feasibility (P&F) Program of the University of Massachusetts Medical School DERC has three principal goals. 1) To provide startup funding for new investigators preparing to embark on careers in diabetes- and endocrinology-related research. 2) To provide established investigators with the opportunity to develop new technologies that may enhance diabetes-related research. 3) To enable established investigators in other fields to initiate research in areas that are related to diabetes. Related to each of these goals is the provision of support and guidance that will allow P&F Program awardees to compete successfully for the extramural funding that will allow them to remain active in diabetes-related research. Since the University of Massachusetts Medical School DERC was initiated in 1983, proposals relevant to each of our goals were received. A total of 41 research proposals funded by the P&F program have been completed. Eight additional research programs funded by the P&F program remain ongoing. Over three fourths of proposal abstracts led to invitations to submit full proposals. Approximately one third of completed proposals were funded. Since the last competing renewal, twenty-two P&F proposals have been funded and/or completed. The investigators of seventeen P&F studies (excluding the five funded in 2004) have received 30 grants from external agencies totaling more than 3.5 million dollars in current year direct costs. Approximately 57 manuscripts have been published by the DERC funded P&F investigators since their P&F award. The DERC is particularly pleased to have enabled at least seven investigators trained in other fields (Chambers, Lien, Chan, Sagerstrom, Kornfeld, Tissenbaum, and Lawson) to undertake programs of research related to diabetes. The Pilot and Feasibility (P&F) Program that is part of this competitive renewal of the University of Massachusetts Medical School DERC is designed very similarly to the program that has demonstrated continuing success since the inception of the program.