Core--Bioengineering for Toxicology

创建毒理学生物工程核心是为了促进新的 与另外两个研究核心的科学焦点相关的实验工具和分析方法，最初侧重于突变和癌症研究核心的活动。我们的目标是开发一系列跨越分子细胞系统长度范围的方法，以解决毒理学和环境健康方面的问题。这些实验工具包括架起细胞培养、动物模型和人类之间桥梁的组织工程生理生物反应器，以及允许通过扫描组织和组织模型中的大量细胞来原位量化单细胞凋亡和DNA重组等事件的多光子成像方法。分析方法包括信号转导网络的统计(贝叶斯)和确定性模型以及蛋白质相互作用的计算模型。 不同细胞隔间的上下文。该核心的具体目标是：(1)为将新的生物工程实验和分析方法引入毒理学和环境健康问题的研究提供一种机制。(2)将新的实验工具和新的分析方法联系起来，以描述DNA损伤、修复、突变和环境因素诱发的致癌过程中的分子到系统水平的事件。(3)进一步开发研究项目和方案，以解决 暴露于环境和内源性因素、基因变化、癌症和其他疾病，重点是建立更好的人类状况模型。(4)促进毒理学生物工程研究核心成员之间的互动，并促进该研究核心成员与其他两个研究核心成员之间的互动，目标是 创建新的研究项目和计划。(5)促进开发和获取中心设施核心的新技术，以促进毒物核心生物工程的研究。(6)将麻省理工学院开发的工程系统和工具传播给更广泛的毒理学和环境健康研究人员社区。

The Bioengineering for Toxicology core was created to facilitate the development of new experimental tools and analysis methods relevant to the scientific foci of the two other Research Cores with an initial emphasis on activities in the Mutation and Cancer Research Core. Our aim is to develop a range of approaches that span the molecular-cellular-systems length scales to solve problems in toxicology and environmental health. The experimental tools range from tissue-engineered physiological bioreactors that bridge the gap between cell culture, animal models, and humans; and multiphoton imaging methods that allow in situ quantification of events such as single cell apoptosis and DNA recombination by scanning large populations of cells in tissues and tissue models. Analytical methods include statistical (Bayesian) and deterministic models of signal transduction networks and computational models of protein interactions in the context of different cell compartments. The Specific Aims of this Core are: (1) To provide a mechanism for bringing new bioengineering experimental and analytical methods into the study of Toxicology and Environmental Health problems.(2) To link new experimental tools and new analytical methods to describe molecular-to-systems level events in DNA damage, repair, mutagenesis and carcinogenesis induced by environmental agents. (3) To further the development of research projects and programs that address the linkages between exposure to environmental and endogenous agents, genetic change and cancer and other diseases with an emphasis on building better models of the human condition. (4) To promote interaction among the Bioengineering for Toxicology Research Core members, and to promote interactions between members of this and the other two Research Cores with the goal of creating new research projects and programs. (5) To promote the development and acquisition of new technologies in the Center Facilities Cores that will facilitate studies in the Bioengineering for Toxicology Core. (6) To disseminate engineered systems and tools developed at MIT to a broader community of toxicology and environmental health researchers.