Cancer Center Support Grant (CCSG)

描述(由申请人提供)：爱荷华大学霍尔顿综合癌症中心(HCCC)是爱荷华大学的基质癌症中心，正在申请续签其癌症中心支持拨款。这是HCCC首次提出竞争性续签申请。 爱荷华大学癌症中心成立于1980年，当时它获得了爱荷华州董事会的特别“中心称号”。它负责协调和促进癌症活动，包括与癌症相关的研究、临床护理和整个大学的教育。癌症中心在1981-84年期间是NCI指定的癌症中心，但拨款和NCI的认可没有续签。20世纪90年代中期，加强癌症中心的机构承诺重新抬头。在20世纪90年代末，两次试图获得NCI称号的尝试都没有成功。乔治·韦纳博士于1998年底被任命为癌症中心主任，根据1999年10月提交的拨款，爱荷华大学癌症中心于2000年获得CCSG资助和NCI指定为综合癌症中心。2001年，该中心更名为霍尔顿综合癌症中心(HCCC)，以表彰爱荷华州威廉斯堡的霍尔顿家族提供的主要支持。HCCC继续加强，同行评审的研究资金、慈善事业以及获得世界级研究和临床设施的机会大幅增加。HCCC在癌症研究和治疗方面的地方、区域和国家形象越来越高。HCCC在该机构中的作用越来越大，严格的规划和评估活动使HCCC能够不断解决如何加强当前癌症研究专业知识的领域，确定潜在有价值的新调查领域，并解决获得临床护理和临床试验方面的差距等重要问题。 本提案“基本特征”一节的“组织能力”部分提供了母国协调委员会的组织细节。简而言之，HCCC是一个基质癌症中心，成员来自6所学院和36个系。所有成员都位于爱荷华州爱荷华市的同一校区，所有临床活动都在爱荷华大学医院和诊所举行。 HCCC由HCCC主任George Weiner博士领导，他向医学院院长报告与研究相关的问题，并向医院主任兼首席执行官报告与临床相关的问题。中心主任由1名副主任和6名副主任(基础研究、临床研究、人口研究、研究基础设施、行政和临床事务)协助。研究方案正式向特定的副主任报告，但由于每个方案的翻译性质，每个副主任向每个方案提供投入。HCCC的主要理事机构是执行委员会。该委员会由副主任、项目负责人和母婴健康中心内选定的其他负责人组成。协委会其他活跃的委员会包括副主任委员会(作为空间委员会)、成员委员会、研究审查委员会、礼宾审查和监测委员会、数据安全监测委员会、宣传委员会、外部咨询委员会和内部咨询小组。

DESCRIPTION (provided by applicant): The University of Iowa Holden Comprehensive Cancer Center (HCCC), a matrix cancer center at the University of Iowa, is applying for renewal of its Cancer Center Support grant. This is the first competitive renewal application for the HCCC. The Cancer Center at the University of Iowa was established in 1980 when it received special "Center Designation" from the Iowa State Board of Regents. It was charged with coordinating and promoting cancer activities including cancer-related research, clinical care and education across the University. The Cancer Center was an NCI-designated cancer center from 1981-84, but the grant and NCI recognition were not renewed. There was a resurgence of institutional commitment to strengthening the Cancer Center in the mid 1990s. In the late 1990s, two attempts at obtaining NCI designation were unsuccessful. Dr. George Weiner was named Cancer Center Director in late 1998, and, based on a grant submitted in October 1999, the University of Iowa Cancer Center received CCSG funding and NCI designation as a Comprehensive Cancer Center in 2000. In 2001, the center was renamed the Holden Comprehensive Cancer Center (HCCC) in recognition of major support provided by the Holden family of Williamsburg, Iowa. The HCCC has continued to strengthen with significant increases in peer-reviewed research funding, philanthropy, and access to world-class research and clinical facilities. The HCCC has a growing local, regional and national profile related to cancer research and treatment. The HCCC has a growing role in the institution, and rigorous planning and evaluation activities are allowing the HCCC to continually address how it can strengthen areas of current cancer research expertise, identify potentially valuable new areas of investigation, and address important issues such as disparities in access to clinical care and clinical trials. Organizational details of the HCCC are provided in the "Organizational Capabilities" portion of the "Essential Characteristics" section of this proposal. Briefly, the HCCC is a matrix cancer center that draws membership from 6 colleges and 36 departments. All members are located on the same campus in Iowa City, Iowa, and all clinical activities take place at the University of Iowa Hospitals and Clinics. The HCCC is led by the HCCC Director, Dr. George Weiner, who reports to the Dean of the College of Medicine for research related issues, and to the Hospital Director and CEO for clinically related issues. The HCCC Director is assisted by a Deputy Director and 6 Associate Directors (Basic Research, Clinical Research, Population Research, Research Infrastructure, Administration and Clinical Affairs). Research programs report formally to specific Associate Directors, however because of the translational nature of each of the programs, input is provided from each of the Associate Directors into each of the programs. The primary governing body of the HCCC is the Executive Committee. This committee is composed of the Associate Directors, program leaders, and selected other leaders within the HCCC. Other active HCCC committees include the Associate Director's Committee (that serves as the space committee), the Membership Committee, Research Review Committee, Protocol Review and Monitoring Committee, Data Safety Monitoring Committee, Advocacy Committee, External Advisory Committee and the Internal Advisory Panel.