Liver Center

描述（由申请人提供） 加州大学旧金山分校弗朗西斯科的肝脏中心是一个 由基础和临床科学家组成的跨学科联盟，致力于 了解肝脏的生物学和病理学以及治疗 肝脏疾病自1975年成立以来，它经历了不断的 进化，以应对当前的科学挑战，其执行委员会 监测研究进展，并提出倡议，以开辟新的领域。的 目前，中心研究的主要路线是由五个相互关联的 主题：（1）免疫学;（2）代谢，损伤和修复;（3）遗传学和 发展;（4）肝癌;和（5）病毒性肝炎。三 出现了免疫学、遗传与发育和肝癌等主题 在本供资期间，通过征聘新成员， 与有组织的研究单位结盟。在过去两年中， 多年来一直参与加州大学旧金山分校癌症中心，并导致准备一个 申请NCI SPORE治疗肝癌。该中心支持四个核心 设施：（1）细胞和组织生物学;（2）临床和转化 研究;（3）显微镜和先进成像;（4）分子分析。四个科学核心不仅提供直接的研究 支持，但也是新合作的场所，也是新合作的切入点。 成员最后，中心通过访问科学家促进科学交流 计划，研讨会系列，及其年度科学务虚会。在2000-01年度， 一学年，这些计划带来了五个基础生物学的主要研究人员 或翻译科学，其工作与研究特别相关， 中心的主题。该中心继续扩大对成员的支持 通过战略伙伴关系，最近与退伍军人 管理，加州大学旧金山分校癌症中心和生物医学研究生课程 以理工科为重除了这些附属机构外，中心还与下列机构保持密切联系： 加州大学旧金山分校的免疫学和发育生物学项目。其供资基础继续扩大，该机构的支持也持续不断 而且强壮基础生物学和基础生物学应用的机会 临床肝病的科学从未如此伟大，该中心是 准备催化这些领域的发现。

DESCRIPTION (provided by applicant) The Liver Center of the University of California, San Francisco is an inter-disciplinary consortium of basic and clinical scientists dedicated to understanding the biology and pathobiology of the liver and the treatment of liver diseases. From its inception in 1975, it has undergone continual evolution to meet current scientific challenges, with its Executive Committee monitoring research progress and creating initiatives to open up new areas. The main lines of Center research at present are represented by five inter-related themes: (1) Immunology; (2) Metabolism, Injury and Repair; (3) Genetics and Development; (4) Liver Cancer; and (5) Viral hepatitis. Three themes-Immunology, Genetics and Development, and Liver Cancer-have emerged during the current funding period through recruitment of new members and alliances with organized research units. A major initiative over the past two years has involved the UCSF Cancer Center and resulted in preparation of an application for an NCI SPORE in liver cancer. The Center supports four core facilities: (1) Cell and Tissue Biology; (2) Clinical and Translational Research; (3) Microscopy and Advanced Imaging; (4) Molecular Analysis. The four scientific Cores not only provide direct research support but are a venue for new collaborations and an entry point for new members. Finally, the Center fosters scientific exchange through a Visiting Scientist Program, a Seminar Series, and its Annual Scientific Retreat. In the 2000-01 academic year, these programs brought five leading researchers in basic biology or translational science whose work has particular relevance to the research themes of the Center. The Center continues to expand its support of member science through strategic partnerships, most recently with the Veterans Administration, the UCSF Cancer Center, and the graduate program in Biomedical Sciences. In addition to these affiliations, the Center enjoys close links with the UCSF programs in Immunology and Developmental Biology, respectively. Its funding base continues to grow, and support from the institution is sustained and strong. The opportunities in basic biology and in the application of basic science to clinical liver disease have never been greater, and the Center is poised to catalyze discovery in these areas.