HAWAII CLINICAL RESEARCH NETWORK FOR HEALTH EQUITY

夏威夷健康公平临床研究网络

• 批准号: 10709897
• 负责人: Venkataraman Balaraman
• 金额: $ 149.35万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-24 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10709897
• 关键词: Address; Adherence; Age; Agreement; Cerebrovascular Disorders; Chronic Kidney Failure; Clinic; Clinical Research; Communities; Data; Databases; Development; Diabetes Mellitus; Disease; Disease Management; Early Diagnosis; Electronic Health Record; Enrollment; Ensure; Ethnic Origin; Ethnic Population; Fatty Liver; Fatty acid glycerol esters; Federally Qualified Health Center; Filipino; General Population; Geography; Goals; Grant; Guidelines; HIV; Hawaii; Health; Health Disparities Research; Health system; Homelessness; Indigenous; Infrastructure; Institutional Review Boards; Island; Link; Liver; Liver Fibrosis; Liver diseases; Logistics; Longevity; Malignant neoplasm of lung; Monitor; Native Hawaiian or Other Pacific Islander; Obesity; Pacific Ocean; Patients; Persons; Phase; Pilot Projects; Policies; Population; Preparation; Prevalence; Primary Care; Procedures; Process; Protocols documentation; Public Health; Registries; Research; Research Design; Research Personnel; Research Project Grants; Risk; Rural Community; Secure; Sexual and Gender Minorities; System; Translational Research; Underinsured; Uninsured; Update; Vulnerable Populations; chronic liver disease; clinical research site; comorbidity; data enclave; data repository; elastography; fatty liver disease; gender minority group; health care delivery; health disparity; health equity; interest; malignant breast neoplasm; medically underserved population; non-alcoholic fatty liver disease; patient safety; population based; primary care clinic; primary care setting; racial diversity; recruit

Project Summary/Abstract The overall goal of this application is to organize a local consortia of ambulatory primary care settings in Hawaii to form the Hawaii Clinical Research Network for Health Equity (HICRN-HE). The clinical research network will focus on the health disparity needs of the Indigenous Pacific People (IPP)–defined as Native Hawaiians, other Pacific Islanders, and Filipinos. The 2 largest health systems in Hawaii providing primary care to a substantial number of IPP [the Queen’s Health System (QHS) and Hawaii Pacific Health (HPH)] and Federally Qualified Health Centers on Oahu will be invited to join the HICRN-HE. The UG3 (first 2 years of the grant) phase will be devoted to developing the infrastructure for HICRN-HE. A secure analyzable and regularly updated patient data repository derived from electronic health records from QHS and HPH will be established to support database analyses of health disparity issues. A Clinical and Translational Research Registry will be created and maintained to link interested local researchers and their research capabilities with those seeking researchers for clinical research/trials. The HICRN-HE will develop a framework for monitoring the implementation phase of HICRN-HE clinical studies to ensure patient safety, adherence to study protocol, and ability to meet recruitment goals. The UH3 phase (years 3-5 of the grant) will be devoted to implementing 2 projects under the thematic health disparity problem of Non-Alcoholic Fatty Liver Disease (NAFLD). Project 1 will focus on NAFLD over the Lifespan in Hawaii and assess the prevalence, risk, co-morbidities, and age at onset of NAFLD in IPP. Project 2 will focus on rates and risks of NAFLD among our sexual and gender minority groups living with HIV to uncover the HIV-specific factors that may contribute to risk above and beyond those in the general population.

项目摘要/摘要 这个应用程序的总体目标是在夏威夷组织一个当地的流动初级保健机构联合体 成立夏威夷卫生公平临床研究网络(HICRN-HE)。临床研究网络将 重点关注土著太平洋人(IPP)的健康差距需求--定义为土著夏威夷人，其他 太平洋岛民和菲律宾人。夏威夷两个最大的卫生系统为大量的人提供初级保健 IPP[女王健康系统(QHS)和夏威夷太平洋健康(HPH)]的数量和联邦资格 瓦胡岛的卫生中心将被邀请加入HICRN-HE。UG3(赠款的头两年)阶段将是 致力于为HICRN-HE开发基础设施。一位安全、可分析并定期更新的患者 将建立来自QHS和HPH的电子健康记录的数据存储库，以支持 健康差距问题的数据库分析。将创建临床和翻译研究注册中心 并保持将感兴趣的当地研究人员及其研究能力与那些寻求 临床研究/试验的研究人员。HICRN-HE将制定一个框架，以监测 HICRN-HE临床研究的实施阶段，以确保患者安全，遵守研究方案，以及 有能力达到招聘目标。UH3阶段(赠款的第3-5年)将专门用于执行2 非酒精性脂肪性肝病(NAFLD)健康差距问题专题下的项目。项目1 将重点关注夏威夷的NAFLD，并评估患病率、风险、合并症和年龄 非酒精性脂肪肝在IPP中的发病。项目2将侧重于性和性别少数群体中NAFLD的发病率和风险 艾滋病毒携带者群体，以揭示可能导致风险的艾滋病毒特有因素 在普通人群中。