HAWAII CLINICAL RESEARCH NETWORK FOR HEALTH EQUITY

项目总结/摘要 这个应用程序的总体目标是在夏威夷组织一个当地的流动初级保健机构联盟 成立了夏威夷健康公平临床研究网络。临床研究网络将 重点关注土著太平洋人（IPP）的健康差异需求-定义为夏威夷土著人，其他 太平洋岛民和菲律宾人。夏威夷最大的两个卫生系统为大量的 IPP [女王卫生系统（QHS）和夏威夷太平洋卫生系统（HPH）]和联邦资格 将邀请奥廷加的保健中心加入该方案。UG 3（赠款的前两年）阶段将是 致力于开发生物医学和高科技的基础设施。一个安全的可分析和定期更新的病人 将建立来自QHS和HPH的电子健康记录的数据存储库，以支持 健康差距问题的数据库分析。将创建临床和转化研究登记处 并保持联系感兴趣的当地研究人员和他们的研究能力， 临床研究/试验的研究人员。该网络将制定一个框架， 实施阶段的CRTRN-HE临床研究，以确保患者安全，遵守研究方案，以及 达到招聘目标。UH 3阶段（赠款的第3-5年）将致力于实施2 在非酒精性脂肪肝（NAFLD）的健康差距问题下开展的项目。项目1 将重点关注夏威夷终身的NAFLD，并评估患病率、风险、合并症和年龄， 在IPP中发生NAFLD。项目2将重点关注我们的性和性别少数群体中NAFLD的发病率和风险 艾滋病毒感染者群体，以揭示可能导致风险超过这些风险的艾滋病毒特异性因素， 在一般人群中。

Project Summary/Abstract The overall goal of this application is to organize a local consortia of ambulatory primary care settings in Hawaii to form the Hawaii Clinical Research Network for Health Equity (HICRN-HE). The clinical research network will focus on the health disparity needs of the Indigenous Pacific People (IPP)–defined as Native Hawaiians, other Pacific Islanders, and Filipinos. The 2 largest health systems in Hawaii providing primary care to a substantial number of IPP [the Queen’s Health System (QHS) and Hawaii Pacific Health (HPH)] and Federally Qualified Health Centers on Oahu will be invited to join the HICRN-HE. The UG3 (first 2 years of the grant) phase will be devoted to developing the infrastructure for HICRN-HE. A secure analyzable and regularly updated patient data repository derived from electronic health records from QHS and HPH will be established to support database analyses of health disparity issues. A Clinical and Translational Research Registry will be created and maintained to link interested local researchers and their research capabilities with those seeking researchers for clinical research/trials. The HICRN-HE will develop a framework for monitoring the implementation phase of HICRN-HE clinical studies to ensure patient safety, adherence to study protocol, and ability to meet recruitment goals. The UH3 phase (years 3-5 of the grant) will be devoted to implementing 2 projects under the thematic health disparity problem of Non-Alcoholic Fatty Liver Disease (NAFLD). Project 1 will focus on NAFLD over the Lifespan in Hawaii and assess the prevalence, risk, co-morbidities, and age at onset of NAFLD in IPP. Project 2 will focus on rates and risks of NAFLD among our sexual and gender minority groups living with HIV to uncover the HIV-specific factors that may contribute to risk above and beyond those in the general population.