Bio-Acrylic Acid Production from Seaweed (BAAPS)

每年约有630万吨的丙烯酸，全球市场价值120亿美元，由丙烯(一种化石燃料的衍生物)工业合成，作为纺织品、粘合剂、涂料等的平台化学品。到目前为止，生物合成替代品对工业来说过于昂贵或效率低下。该项目旨在通过从藻类废物中开发一种经济高效的微生物生物合成路线来减少丙烯酸生产过程中的碳排放。方法：-分子遗传学将被用来从养殖的大型藻类中存在的丰富代谢物中产生专有微生物菌株，从而提高生物丙烯酸的产量。-分析化学技术，如层析和质谱学，将用于量化这种高价值化学品的生产。-将调查分批生长条件，并最终在生物反应器环境中通过它们产生的菌株来优化生物丙烯酸的生产。-将设计、测试和优化从培养菌株中提取丙烯酸的方法。

Annually ~6.3 million tonnes of acrylic acid, with a global market of $12 billion, is industrially synthesised from propylene (a fossil fuel derivative) as a platform chemical for e.g textiles, adhesives, paints. To date, biosynthetic alternatives are too costly or inefficient for industry. This project aims to reduce carbon emissions from acrylic acid production by developing a cost-effective microbial biosynthetic route from algal waste. Methodology:- Molecular genetics will be used to generate proprietary microbial strains with enhanced bio-acrylic acid production from abundant metabolites present in farmed macroalgae. - Analytical chemistry techniques, such as chromatography and mass spectroscopy, will be used to quantify production of this high-value chemical. - Growth conditions in batch and ultimately in bioreactor settings that optimise bio-acrylic acid production by the strains they generate will be investigated. - A method for acrylic acid extraction from the cultured strains will be devised, tested and optimised.