How do bacteria contribute to aggressive prostate cancer?

前列腺癌（PCa）是全球男性中第二大常见癌症，每年约有307,000名男性死亡。众所周知，细菌和病毒等传染因子与宫颈癌、胃癌和膀胱癌等多种癌症的发生有关。前列腺癌的病因和晚期疾病的发展仍不清楚，但有充分的证据表明，感染因子可能是一个原因。该项目将研究感染性细菌因子如何参与PCa的发展，或者它们的存在是否是机会性的。该项目将对与不良结果相关的潜在新型细菌进行测序和鉴定；通过挖掘现有的癌症和尿液数据集，确定细菌、侵袭性疾病和人类癌细胞变化之间的关系；并研究宿主和细菌之间的作用机制。这项研究有可能揭示如何利用细菌来预测接受的最佳治疗，并揭示预防或阻止侵袭性癌症的新治疗可能性。

Prostate cancer (PCa) is the second most common cancer in men worldwide and ~307,000 men die every year. It is known that infectious agents, such as bacteria and viruses, are involved in the development of a variety of cancers such as cervical, stomach, and bladder cancer. The causes of PCa and the development of advanced disease remains obscure, but there is good evidence that infectious agents could be one cause.This project will examine the question of how infectious bacterial agents are involved in the development of PCa, or whether their presence is opportunistic. The project will sequence and identify potentially novel bacteria that are associated with a poor outcome; determine the associations between bacteria, aggressive disease, and human cancer cell changes by mining existing cancer and urine datasets; and investigate mechanisms of action between host and bacteria. This research has the potential to reveal how bacteria can be used to predict the best treatment to receive and reveal new treatment possibilities to prevent or halt aggressive cancer.