HYPOGLYCEMIA AND ENDOTHELIAL FUNCTION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。低血糖是1型糖尿病的常见事件，具有显著的后果。急性心肌梗死是一种罕见的低血糖后果。目前尚不清楚低血糖如何导致心肌梗死。一种可能是通过几种可能的机制损害内皮功能。这项建议旨在获得关于低血糖对健康对照组受试者内皮功能影响的初步数据。如果发现低血糖损害内皮功能，未来的研究将继续探索这种影响的持续时间和机制，它在1型糖尿病和潜在的2型糖尿病中的反应是不同的。在高胰岛素血症葡萄糖钳夹前和期间，通过反应性充血对10名健康对照组受试者的内皮功能进行测量。每个受试者将进行两次研究，一次使用降糖钳夹，一次在正常血糖钳夹期间。这将使AS能够将高胰岛素血症的影响与低血糖的影响分开。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypoglycemia is a common event in type 1 diabetes that has significant consequences. Acute myocardial infarction is a reported rare consequence of hypoglycemia. It is unclear how hypoglycemia may lead to myocardial infarction. One possibility is through impairment of endothelial function through several possible mechanisms. This proposal is designed to gain preliminary data on the effect of hypoglycemia on endothelial function in healthy control subjects. If hypoglycemia is found to impair endothelial function future studies will be pursued to explore the duration and mechanism of this effect and it the responses are different in type 1 and potentially type 2 diabetes. Endothelial function will measured via reactive hyperemia in ten healthy control subjects before and during hyperinsulinemic glucose clamp. Each subject will be studied twice once with hypoglycemic clamp and once during euglycemic clamp. This will allow as to separate the effect of hyperinsulinemia from the effect of hypoglycemia.