DOES HYPERGLYCEMIA OR HYPERINSULINEMIA CAUSE VASODILATION DURING INSULIN CLAMP?

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。在成人中，血压正常和高血压患者的内皮功能与胰岛素敏感性之间存在密切联系。这种关系被认为可能在胰岛素抵抗、动脉粥样硬化、高血压和2型糖尿病等“代谢综合征”的发展中发挥作用。 在这项研究中，我们假设在成人中观察到的胰岛素敏感性和内皮功能之间的正相关性延伸到正常青少年，内皮功能的差异可能有助于解释：1。青春期青少年胰岛素敏感性降低，2。非裔美国人的胰岛素敏感性降低为了解决这些假设，我们将使用前臂反应性充血反应来测量内皮功能，并使用稳定标记的频繁采样静脉葡萄糖耐量试验来测量胰岛素敏感性。以下问题将得到解决1.青少年血管闭塞（反应性充血反应）后前臂血流和/或血管阻力的百分比变化与胰岛素敏感性呈正相关吗？ 2.青春期青少年的反应性充血反应是否减少？ 3.与白人青少年相比，非裔美国人的反应性充血反应是否减少？

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In adults there is a close link between endothelial function and insulin sensitivity in both normotensive and hypertensive subjects. This relationship is thought possibly to play a role in the development of the "metabolic syndrome" of insulin resistance, atherosclerosis, hypertension and type 2 diabetes. In this study we hypothesize that the positive correlation between insulin sensitivity and endothelial function seen in adults extends to normal adolescents and that differences in endothelial function may help explain: 1. Decreased insulin sensitivity in pubertal adolescents, 2. Decreased insulin sensitivity in African-Americans and To address these hypotheses we will use the forearm reactive hyperemic response to measure endothelial function and the stable labeled frequently sampled intravenous glucose tolerance test to measure insulin sensitivity. The following questions will be addressed 1. Are the percent changes in the forearm blood flow and/or vascular resistance following vascular occlusion (reactive hyperemic responses) positively related to insulin sensitivity in adolescents? 2. Are reactive hyperemic responses decreased in pubertal adolescents? 3. Are reactive hyperemic responses decreased in African-American compared to Caucasian adolescents?