UCSF CLINICAL RESEARCH CURRICULUM AWARD

描述：说明申请的广泛、长期目标和具体目的，并参考项目与健康的关系。描述

DESCRIPTION: State the application's broad, long-term objectives and specific aims, making reference to the health relatedness of the project. Describe concisely the research design and methods for achieving these goals. Avoid summaries of past accomplishments and the use of the first person. This abstract is meant to serve as a succinct and accurate description of the proposed work when separated from the application. If the application is funded, this description, as is, will become public information. Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE SPACE PROVIDED. Since receiving our first K30 award in 1999, the UCSF Training In Clinical Research program (TICR) has made great progress toward our goal of increasing the number, diversity and quality of clinical investigators. Through our revised and expanded 8-week Clinical Research Workshop, our formalized 1-year Advanced Training in Clinical Research Certificate Program, and our new 2-year Master's in Clinical Research Degree Program, we have trained over 700 new clinical researchers during the last 5 years. This has involved increasing the number of formal UCSF courses from 2 to 24; creating a structured approach to mentoring; disseminating our teaching methods by publishing widely-used texts and creating an open-access website; and using student evaluations and advice from peers to continuously improve our strategies and performance. Our philosophy is to invite students to create the actual products involved in clinical research: For our cornerstone Clinical Research Workshop, for example, each scholar designs a protocol for an actual study; for our Master's Degree she/he designs, conducts, analyzes, presents and submits for publication a clinical research study. During the next 5 years, we plan to continue all these successful programs and strategies, and to enhance and expand on them in a number of ways. We are developing 2 new degree programs: a joint PhD with the UC Berkeley School of Public Health, and a new 5-year MD-Master's Degree option for UCSF medical students. We plan improvements in each of our existing courses, and we will create 6 new courses including a 3-quarter series in genetic epidemiology and statistical genetics. We aim to double the number of master's scholars matriculating each year (to N=20), with particular attention to increasing the numbers from under- represented UCSF departments and racial backgrounds. We will create an opportunity for scholars to observe and discuss how an IRB operates, and begin requiring MCR candidates to orally defend their thesis and demonstrate methodological mastery to their Committee. We plan innovations to enhance mentoring and career development including structured guidance for mentors, weekly research clinics, and semi- annual career development forums. Several new texts are in progress, and we will take steps to increase the use of our teaching materials by other institutions. New focus groups, exit interviews, and alumni reunions will enhance our evaluation process, and we will use this information and advice from internal and external advisory committees and colleagues at other K30 programs in an ongoin 9 effort to improve our program. PERFORMANCE SITE(S) (organization, city, state) University of California, San Francisco (UCSF), San Francisco, California KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Stephen B Hulley MD MPH UCSF Deborah Grady MD MPH UCSF Jeffrey N Martin MD MPH UCSF Kirsten Bibbins-Domingo, PhD, MD UCSF Andrew Bindman MD UCSF Stanton A Glantz PhD UCSF David V Glidden PhD UCSF Joan F Hilton ScD MPH UCSF Elizabeth Holly, PhD UCSF James G Kahn MD MPH UCSF Michael Kohn MD MPP UCSF _i_teJ_/_r_T_r_n Statement. Aoolicable to SBIR/STI'R Only. See in_j_ior_. [] Yes [] in the format shown below. Role on Project Program Director Co-Director Co-Director Faculty Member Course Director Course Director Course Director Course Director Course Director Course Director Course Director No Form Page 2 Hulley, Stephen B, MD Key personnel (continued from previous page) Name Organization Role on Project Bernard Lo MD UCSF Course Director Charles McCulloch, PhD UCSF Advisory Committee John M Neuhaus PhD UCSF Course Director Thomas Newman MD MPH UCSF Course Director Eliseo J Perez-Stable MD UCSF Course Director Mark J Pletcher MD UCSF Course Director Ida Sim MD PhD UCSF Course Director Saunak Sen PhD UCSF Course Director Mary A Whooley MD UCSF Course Director Joseph Wiemels PhD UCSF Course Director John Witte PhD UCSF Course Director 3 UNIVERSITY OF CALIFORNIA, SAN FRANCISCO CLINICAL RESEARCH CURRICULUM AWARD (K30)