Functional dissection of the malaria RhopH complex and its contribution to new permeation pathways

疟原虫入侵和改造宿主红细胞的能力是其导致疟疾的最重要因素。该项目旨在了解红细胞入侵期间从专门的棒状细胞器分泌的蛋白质如何帮助疟原虫重塑红细胞，以便寄生虫能够获得生存所需的重要营养物质。这项研究将验证靶向棒状蛋白的药物是否是可行的药物靶点。

The ability of Plasmodium to invade and remodel its host erythrocyte are the most significant contributors to its ability to cause the disease malaria. This project aims to understand how proteins secreted from a specialized rhoptry organelle during erythrocyte invasion help Plasmodium to remodel the erythrocyte so that the parasite can gain access to the vital nutrients it requires for survival. This research will validate whether drugs targeting the rhoptry proteins are viable drug targets.