A Natonal Resource for Postmortem Brain Research

描述(申请人提供)：哈佛脑组织资源中心，HBTRC，RO1赠款的具体目标是1)获取死后脑，2)处理和存储死后脑，3)分发组织和信息。本补充资料旨在为自闭症组织计划(ATP)提供支持，以扩大和加强这三个领域，以促进将代表自闭症谱系障碍的脑组织获取到主库中，并促进对生物医学研究资源的最科学负责任的使用。为了最大限度地收集脑组织，ATP让自闭症社区的人意识到需要脑组织，准确地解释如何捐赠脑组织，以及在遇到死亡危机时如何获得必要的捐赠支持。其次，ATP已经启动了MyATP项目，旨在为几个州的优化脑组织开发快速尸检。最近扩大了一个组织咨询委员会(TAB)，由在一系列组织相关学科方面经验丰富的有成就的科学家组成，负责审查大脑处理和存储方法，以实现自闭症组织的最佳利用。第三，TAB在审查组织的书面申请后，监督组织向调查人员的分配，并负责就未来的研究方向提出建议。为了支持这第三个目标，自闭症组织计划为研究人员维护一个数据库和网站门户。脑组织的采集和检查是自闭症研究的必要组成部分，为直接研究脑细胞、神经递质系统和基因表达提供了一种方法，以寻找发育变化的迹象，识别诊断的生物标记物，并提出潜在的治疗建议。

DESCRIPTION (provided by applicant): The specific aims of the Harvard Brain Tissue Resource Center, HBTRC, RO1 grant are to 1) Acquire Postmortem Brains, 2) Process and Store Postmortem Brains and 3) Distribute Tissue and Information. This supplement is intended to provide support to the Autism Tissue Program (ATP) to expand and augment these three areas to promote the acquisition of brain tissue representing autism spectrum disorders into a main repository and to promote the most scientifically responsible use of the resource for biomedical research. To maximize brain tissue collection, the ATP makes those in the autism community aware of the need for brain tissue, explains exactly how to donate brain tissue, and how to obtain the necessary support for donation when involved in the crisis of a death. Second, the ATP has launched the MyATP project aimed at developing rapid autopsy for optimized brain tissue in several states. A recently expanded Tissue Advisory Board (TAB), comprised of accomplished scientists who are experienced in an array of tissue- related disciplines, is in place to review brain processing and storage methods that would allow for optimal use of autism tissue. Third, the TAB oversees the distribution of tissue to investigators after reviewing written applications for tissue and is charged with the responsibility of making recommendations regarding future research directions. In support of this third aim, the Autism Tissue Program maintains a database and website portal for researchers. The acquisition and examination of brain tissue is a necessary component of autism research providing a way for the direct study of brain cells, of neurotransmitter systems and of gene expression for signs of developmental changes, to identify biomarkers for diagnosis and to suggest potential treatments.