Functional pharmacogenetics: Analysis of the functional effect of the IL28B genotype on hepatitis C virus infection and treatment response.

据估计，全世界3%的人口感染了丙型肝炎病毒（HCV）。由于低的自发清除率和对治疗的不良反应，许多感染者将发展为HCV的长期并发症。最近的研究已经确定了一种遗传变异，它与HCV的自发病毒清除和对HCV治疗的反应显著相关。我们建议进一步研究这种人类基因型对药物反应的作用的功能基础。

An estimated 3% of the world�s population is infected with hepatitis C virus (HCV). With low spontaneous clearance rates and often a poor response to treatment many infected individuals will develop long term complications from HCV. Recent studies have identified a genetic variant that is significantly associated with spontaneous viral clearance of HCV and response to treatment for HCV. We propose to further investigate the functional basis for the effect of this human genotype on drug response.