Long-acting depots for treatment of a globally neglected disease

小分子长效注射剂（莱什）是制药行业关注的一个快速扩展的领域，正在探索用于一系列疾病（如传染病（包括全球被忽视的疾病）和癌症）的新机会。此外，对莱什给药后药物和制剂的注射后分布以及这如何影响药物释放仍知之甚少。因此，该项目的目标是开发一种用于治疗全球被忽视的疾病的药物的长效贮库制剂和新型成像技术（3D OrbiSIMS和ToF西姆斯），以更好地观察注射部位的体内行为。这将提高理解，使合理的配方开发在未来。

Long acting injections (LAIs) of small molecules are a rapidly expanding area of interest for the pharma industry, with new opportunities being explored for a range of conditions such as infectious disease (including globally neglected diseases), and cancer. Also, the post injection distribution of drug and formulations after administration of LAIs, and how this impacts drug release is still poorly understood. Hence the goals of this project are to develop a long acting depot formulation for a drug used to treat a globally neglected disease and novel imaging techniques (3D OrbiSIMS and ToF SIMS) to better characterise in vivo behaviour at the injection site. This will improve understanding to enable rational formulation development in the future.