Epidemiology of Dementia in Older Dialysis Patients

描述（由申请人提供）：候选人：Anne Murray，医学博士，理学硕士，是一位接受过研究员培训的老年病学家，拥有流行病学硕士学位，也是明尼苏达大学附属教学医院亨内平县医疗中心的一名医生。她也是肾脏病学分析服务的研究员，这是一个流行病学实验室，也是NIH美国肾脏数据系统（USRDS）数据库的存储库。Murray博士的近期目标是从事透析患者认知障碍的流行病学和预防研究。职业目标：Murray博士的近期职业目标包括：1）神经心理学，研究设计，纵向分析和研究道德行为的高级课程，2）与她的导师合作，通过定期安排的会议和指导阅读，进一步发展她在肾脏疾病认知障碍领域的研究技能，3）在导师的指导下，对透析患者的认知障碍的患病率和进展进行为期三年的纵向研究，4）继续使用USRDS数据库对透析患者中痴呆症的流行病学进行分析，以及5）在该奖项的最后一年，制定一项提案，为慢性肾脏疾病患者认知障碍的发生率和风险因素的前瞻性研究获得资金，以前称为慢性肾功能不全。Murray博士的长期职业目标是在肾脏疾病和其他慢性疾病的认知障碍流行病学领域获得独立的调查员。研究计划：在五年的奖励期内，Murray博士计划利用她的试点数据和USRDS数据库的分析结果，对双城透析患者认知障碍的患病率和进展进行前瞻性纵向研究。本研究将检验以下假设：1）透析患者的认知功能障碍患病率高于一般人群，2）认知功能障碍的风险随透析持续时间（年）而增加，3）年龄、基线时改良简易精神状态检查（3MS）评分、教育和卒中史将是透析患者认知功能障碍进展率的强预测因素。随后，Murray博士计划与她的导师合作撰写一份主要提案，以研究慢性肾脏疾病患者认知障碍的流行病学。

DESCRIPTION (provided by applicant): Candidate: Anne Murray, M.D., M.Sc., is a fellowship-trained geriatrician with a Masters in Epidemiology and a staff physician at Hennepin County Medical Center, a teaching hospital affiliated with the University of Minnesota. She is also an investigator with Nephrology Analytical Services, an epidemiology laboratory and repository for the NIH's United States Renal Data System (USRDS) database. Dr. Murray's immediate goal is to pursue research in the epidemiology and prevention of cognitive impairment in dialysis patients. Career Objectives: Dr. Murray's immediate career objectives include: 1) advanced coursework in neuropsychology, study design, longitudinal analysis, and ethical conduct of research, 2) work with her mentors to further develop her research skills in the area of cognitive impairment in renal disease through regularly scheduled meetings and directed readings, 3) conduct a three-year longitudinal study of the prevalence and progression of cognitive impairment in dialysis patients under the guidance of her mentors, 4) continue to conduct analyses on the epidemiology of dementia in dialysis patients using the USRDS database, and 5) during the last year of the award, develop a proposal to obtain funding for a prospective study of the incidence of and risk factors for cognitive impairment in patients with chronic kidney disease, formerly called chronic renal insufficiency. Dr. Murray's long-term career objective is to attain independence as an investigator in the area of epidemiology of cognitive impairment in renal disease and other chronic diseases. Research Plan: During the five-year award period, Dr. Murray plans to use findings from analyses of her pilot data and the USRDS database to conduct a prospective longitudinal study of the prevalence and progression of cognitive impairment in dialysis patients in the Twin Cities. The study will test the hypotheses that 1) dialysis patients have a higher prevalence of cognitive impairment than the general population, 2) the risk of cognitive impairment increases with duration in years of dialysis, and 3) age, Modified Mini-Mental State Examination (3MS) score at baseline, education, and history of stroke will be strong predictors of the rate of progression of cognitive impairment in dialysis patients. Subsequently, Dr. Murray plans to collaborate with her mentors to write a major proposal to examine the epidemiology of cognitive impairment in patients with chronic kidney disease.